Description

3-Chlorofluocinolone Acetonide is a synthetic corticosteroid derivative, specifically a halogenated analog of fluocinolone acetonide. This compound is valued for its potent anti-inflammatory and immunosuppressive properties, making it a critical intermediate in advanced pharmaceutical synthesis. It is primarily required by research institutions and pharmaceutical manufacturers developing topical corticosteroids for dermatological conditions such as eczema, psoriasis, and allergic dermatitis.

Application

• Pharmaceutical Intermediate: Key starting material or intermediate in the synthesis of high-potency topical corticosteroid APIs.
• Dermatological Research: Used in preclinical and clinical research for developing new anti-inflammatory and antipruritic treatments.
• Reference Standard: Serves as an analytical reference standard in quality control laboratories for method development and validation.
• Veterinary Medicine: Potential application in formulating anti-inflammatory treatments for animal skin conditions.
• Cosmeceutical R&D: Investigated for controlled-use applications in specialized cosmetic formulations targeting severe skin inflammation.

Basic Information

Item	Detail
Product Name	3-Chlorofluocinolone Acetonide
CAS No.	87138-77-0
Molecular Formula	C24H28ClFO6
Molecular Weight	466.93 g/mol
Synonyms	3-Chloro-6α,9α-difluoro-11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with acetone; 3-Chloro-6α,9α-difluoro-11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetonide; Chlorinated Fluocinolone Acetonide; 3-Cl-Fluocinolone Acetonide; 3-Chlorofluocinolone 16,17-acetonide
EINECS	Contact for details

Quality Control

Our 3-Chlorofluocinolone Acetonide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, residual solvent analysis, and identity confirmation by IR and NMR spectroscopy. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with relevant research and pharmaceutical intermediate standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.