Description

3α,12-α-Dihydroxy-7-Diazirdinecholanic Acid is a chemically modified bile acid derivative, characterized by the introduction of a diaziridine functional group. This unique structure makes it a valuable intermediate in advanced pharmaceutical research and organic synthesis, particularly for the development of novel therapeutic agents and biochemical probes. It is primarily sought after by research institutions and pharmaceutical companies engaged in medicinal chemistry, metabolic studies, and the synthesis of steroidal compounds.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel steroidal drugs and bioactive molecules targeting metabolic pathways.
• Biochemical Research: Used as a precursor or probe in metabolic studies and enzyme interaction research due to its bile acid backbone.
• Medicinal Chemistry: Serves as a critical scaffold for structure-activity relationship (SAR) studies in drug discovery programs.
• Organic Synthesis: Employed in advanced organic reactions, leveraging the reactive diaziridine group for photoaffinity labeling or cross-linking applications.
• Reference Standard: Used as an analytical standard in quality control laboratories for method development and validation.

Basic Information

Product Name	3α,12-α-Dihydroxy-7-Diazirdinecholanic Acid
CAS No.	86933-63-3
Molecular Formula	C₂₄H₄₀N₂O₄
Molecular Weight	420.59 g/mol
Synonyms	7-Diaziridinyl-3α,12α-dihydroxy-5β-cholan-24-oic Acid; 3α,12α-Dihydroxy-7-diazirin-1-yl-5β-cholan-24-oic Acid; 7-Diaziridinecholanic Acid Derivative; Diaziridine Modified Cholic Acid; 86933-63-3; 3α,12α-Dihydroxy-7-diaziridinylcholanic Acid
EINECS	Contact for details

Quality Control

Our 3α,12-α-Dihydroxy-7-Diazirdinecholanic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your research or development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.