Description

Methyl (S)-4-Chloro-3-Hydroxybutyrate is a high-value chiral building block and key pharmaceutical intermediate. This compound is essential for the stereoselective synthesis of complex molecules, particularly in the production of active pharmaceutical ingredients (APIs) and fine chemicals. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for developing advanced therapeutics and chiral compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of statin drugs (e.g., Atorvastatin, Rosuvastatin) and other cardiovascular and cholesterol-lowering agents.
• Chiral Building Block: Used in asymmetric synthesis to introduce the (S)-4-chloro-3-hydroxybutyrate moiety into complex organic molecules.
• Agrochemical Synthesis: Serves as a precursor in the manufacture of certain chiral pesticides and herbicides.
• Biochemical Research: Employed in enzymatic studies and as a substrate or intermediate in biochemical pathways.
• Fine Chemical Production: Utilized in custom synthesis and the production of specialty chemicals requiring high enantiomeric purity.

Basic Information

Product Name	Methyl (S)-4-Chloro-3-Hydroxybutyrate
CAS No.	86728-93-0
Molecular Formula	C5H9ClO3
Molecular Weight	152.57 g/mol
Synonyms	(S)-Methyl 4-Chloro-3-hydroxybutyrate; (S)-4-Chloro-3-hydroxybutyric Acid Methyl Ester; Methyl (S)-(-)-4-Chloro-3-hydroxybutyrate; (S)-CHBM; (3S)-4-Chloro-3-hydroxybutanoic Acid Methyl Ester; (S)-Methyl 4-chloro-3-hydroxybutanoate; (S)-Me 4-Cl-3-OH-butyrate
EINECS	Contact for details

Quality Control

Our Methyl (S)-4-Chloro-3-Hydroxybutyrate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity (enantiomeric excess) and chemical purity assays, to ensure it meets the high standards required for pharmaceutical and fine chemical applications. Certificates of Analysis (COA) with detailed chromatographic data (HPLC/GC) are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider holding under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.