Description

4,4',4''-Tris(Benzoyloxy)Trityl Bromide is a specialized brominated trityl protecting group reagent with a high molecular weight. This compound is critical for advanced organic synthesis, particularly in the protection of hydroxyl groups during the multi-step synthesis of complex molecules like oligonucleotides and pharmaceuticals. It is primarily needed by research institutions, pharmaceutical R&D laboratories, and fine chemical manufacturers engaged in the production of nucleosides, nucleotides, and other sensitive intermediates.

Application

• Oligonucleotide Synthesis: As a key protecting group reagent for the 5'-hydroxyl function in solid-phase phosphoramidite chemistry.
• Pharmaceutical Intermediates: In the multi-step synthesis of active pharmaceutical ingredients (APIs) requiring selective hydroxyl protection.
• Nucleoside/Nucleotide Chemistry: For the preparation of modified nucleosides used in antiviral and anticancer drug development.
• Peptide Synthesis: Potentially used for the protection of serine, threonine, or tyrosine side chains in complex peptide sequences.
• Material Science Research: As a building block for creating novel dendritic or star-shaped polymers and advanced organic materials.
• Academic & Industrial R&D: For methodological development in synthetic organic chemistry and catalysis studies.

Basic Information

Product Name	4,4',4''-Tris(Benzoyloxy)Trityl Bromide
CAS No.	86610-66-4
Molecular Formula	C48H33BrO6
Molecular Weight	785.68 g/mol
Synonyms	TBTrBr; Tris(4-benzoyloxy)trityl Bromide; 4,4',4''-Tris(benzoyloxy)triphenylmethyl Bromide; TBTO-Tr Bromide; (4-Benzoyloxyphenyl)diphenylmethyl Bromide (derivative); Bromotris(4-benzoyloxyphenyl)methane; Trt(Bz)3-Br; NSC 405124
EINECS	Contact for details

Quality Control

Our 4,4',4''-Tris(Benzoyloxy)Trityl Bromide is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for sensitive synthetic applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP standards where applicable, and our quality system supports compliance with global regulatory requirements for research and pharmaceutical use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive) and light-sensitive. Keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Store away from strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Solubility	Soluble in dichloromethane, DMF, THF; slightly soluble in ether

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.