Description

Poly(Deoxy(Thymidylic Acid-Adenosine 5'-o-Phosphorothioate)) is a chemically modified oligonucleotide, specifically a phosphorothioate-linked dinucleotide. This compound is a critical building block and research tool in the fields of molecular biology and therapeutic nucleic acid development. Its primary value lies in its nuclease-resistant phosphorothioate backbone, which enhances stability for in vitro and in vivo applications. This makes it essential for researchers and manufacturers in biotechnology, pharmaceutical R&D, and diagnostic assay development.

Application

• Therapeutic Oligonucleotide Synthesis: A key phosphorothioate intermediate for constructing antisense oligonucleotides, siRNA, and aptamers with enhanced metabolic stability.
• Molecular Biology Research: Used as a substrate or model compound to study enzyme kinetics, particularly for nucleases and polymerases, and to investigate nucleic acid-protein interactions.
• Diagnostic Probe Development: Serves as a modified component in the design of hybridization probes and primers that require resistance to degradation in complex biological samples.
• Biochemical Tool Manufacturing: Incorporated into kits and reagents for genetic analysis, PCR, and next-generation sequencing applications where standard oligonucleotides are insufficient.
• Pharmaceutical R&D: Utilized in preclinical studies to evaluate the pharmacokinetics and biodistribution of phosphorothioate-containing drug candidates.

Basic Information

Product Name	Poly(Deoxy(Thymidylic Acid-Adenosine 5'-o-Phosphorothioate))
CAS No.	86594-48-1
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	d(TpsA); Thymidylyl-(3'→5')-adenosine, O-Phosphorothioate; Adenosine, 5'-[5-O-[5-(2,4-dioxo-1(2H)-pyrimidinyl)-2-deoxy-β-D-erythro-pentofuranosyl] phosphorothioate]; Phosphorothioate-linked dT-A dinucleotide; d(Thd-ps-Ado); 5'-O-Phosphorothioate of thymidylyl-(3'→5')-adenosine; PS-dinucleotide (T-A)
EINECS	Contact for details

Quality Control

Our Poly(Deoxy(Thymidylic Acid-Adenosine 5'-o-Phosphorothioate)) is produced under stringent quality management systems. Each batch undergoes comprehensive analytical characterization to ensure identity, purity, and consistency, meeting the exacting standards required for life science research and development. Certificates of Analysis (COA) detailing specifications such as purity (HPLC), identity confirmation (MS, NMR), and moisture content are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a desiccated environment. This product is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a dry atmosphere before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to reference
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.