Description

Guanosine-3',5'-Cyclic Monophosphorothioate, Sp-Isomer Sodium Salt is a chemically modified, non-hydrolyzable analog of cyclic GMP (cGMP) designed for advanced biochemical research. This compound is a critical tool for studying cyclic nucleotide-dependent signaling pathways, particularly those involving protein kinase G (PKG), by acting as a potent and selective activator. It is essential for researchers and developers in pharmaceutical discovery, molecular biology, and signal transduction studies who require high-purity, biologically active probes.

Application

• Biochemical Research: As a potent and selective activator of cGMP-dependent protein kinases (PKG) in cell-free and cellular assays.
• Signal Transduction Studies: Investigating the role of cGMP in cardiovascular, neurological, and metabolic pathways without degradation by phosphodiesterases.
• Drug Discovery & Screening: Used in high-throughput screening (HTS) assays to identify novel modulators of the cGMP/PKG pathway for therapeutic development.
• Enzymology: A substrate analog for studying the kinetics and specificity of phosphodiesterases and other nucleotide-binding enzymes.
• Cell Physiology: Probing intracellular mechanisms related to smooth muscle relaxation, platelet aggregation, and neuronal plasticity.
• Reference Standard: Serves as a certified reference material (CRM) for analytical method development and validation in quality control laboratories.

Basic Information

Product Name	Guanosine-3',5'-Cyclic Monophosphorothioate, Sp-Isomer Sodium Salt
CAS No.	86562-10-9
Molecular Formula	C10H11N5Na2O6PS
Molecular Weight	429.23 g/mol
Synonyms	Sp-cGMPS sodium salt; Guanosine 3',5'-cyclic monophosphorothioate, Sp-isomer, sodium salt; 8-Br-Sp-cGMPS (common derivative reference); cGMP-S, Sp-isomer; Sodium Sp-guanosine 3',5'-cyclic phosphorothioate; PKG activator; Non-hydrolyzable cGMP analog; Cyclic GMP phosphorothioate, Sp-isomer
EINECS	Contact for details

Quality Control

Every batch of our Guanosine-3',5'-Cyclic Monophosphorothioate, Sp-Isomer Sodium Salt is manufactured under strict quality management systems. We provide comprehensive analytical documentation to ensure it meets the exacting standards required for research and pharmaceutical development. A detailed Certificate of Analysis (COA), including data for purity (HPLC), identity (NMR, MS), and biological activity, is available for each lot upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated under an inert atmosphere. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Biological Activity (PKG Assay)	≥ 90% of theoretical activity
Endotoxin	< 10 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.