Description

Methoxypolyethylene Glycol 5,000 Acetic Hydrazide is a functionalized mPEG derivative where a reactive hydrazide group is linked to the polymer chain via an acetic acid spacer. This compound is engineered to provide a versatile, water-soluble polymer backbone with a terminal functional group for selective conjugation, particularly with aldehydes and ketones. It is primarily utilized by researchers and manufacturers in the pharmaceutical and bioconjugation sectors for drug delivery system development, protein/peptide modification, and surface functionalization of nanomaterials. The product offers a balance of biocompatibility and controlled reactivity, making it a critical reagent for advanced therapeutic and diagnostic applications.

Application

• Bioconjugation and Protein Modification: Site-specific coupling to carbonyl groups on oxidized glycoproteins or antibody fragments for creating stable conjugates.
• Drug Delivery Systems: Functional component in the synthesis of polymer-drug conjugates (e.g., PEGylation) to improve solubility, stability, and pharmacokinetics of active pharmaceutical ingredients.
• Surface Functionalization: Grafting onto nanoparticles, quantum dots, or solid supports to create hydrophilic, non-fouling surfaces with reactive handles for further coupling.
• Crosslinking Agent: Used in hydrogel formation or biomaterial fabrication where hydrazone bond formation is desired for pH-sensitive linkage.
• Diagnostic Reagent Synthesis: Preparation of labeled probes and contrast agents for imaging and assay development.
• Intermediate for Further Derivatization: Serves as a key building block for synthesizing more complex mPEG-based reagents with tailored functionality.

Basic Information

Product Name	Methoxypolyethylene Glycol 5,000 Acetic Hydrazide
CAS No.	86469-86-5
Molecular Formula	C2n+5H4n+12N2On+3 (n~113)
Molecular Weight	~5,000 g/mol (Average Mn)
Synonyms	mPEG5000-Acetic Hydrazide; mPEG5k-HZ; Methoxy PEG 5000 Acetohydrazide; Poly(ethylene glycol) methyl ether acetic hydrazide (MW 5000); α-Methoxy-ω-hydrazidoacetic acid poly(ethylene glycol); PEG Methyl Ether Acetic Hydrazide (5,000 MW); mPEG-Hydrazide, MW 5000; Acetic hydrazide PEG methyl ether
EINECS	Contact for details

Quality Control

Our Methoxypolyethylene Glycol 5,000 Acetic Hydrazide is manufactured under a quality management system and undergoes rigorous analytical testing to ensure batch-to-batch consistency and high purity. Each lot is characterized for critical parameters including molecular weight distribution, functional group content, and impurity profiles. Certificates of Analysis (COA) detailing specifications and test results are provided with every shipment. We support compliance requirements for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This material is hygroscopic (moisture-sensitive). Allow the sealed container to equilibrate to room temperature before opening to prevent condensation and moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white waxy solid or powder
Identification (IR)	Conforms to structure
Average Molecular Weight (Mn)	5,000 ± 10% (by GPC)
Polydispersity Index (PDI)	≤ 1.05
Hydrazide Content	≥ 90% of theory
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.