Description

1,11-Bis-Maleimidotetraethyleneglycol is a heterobifunctional crosslinking agent featuring a hydrophilic tetraethylene glycol spacer terminated by two maleimide groups. This compound matters for its ability to form stable thioether bonds with sulfhydryl groups under mild, aqueous conditions, making it a critical reagent for site-specific bioconjugation. It is primarily needed by researchers and manufacturers in the biopharmaceutical and diagnostics industries for applications such as antibody-drug conjugate (ADC) development, protein-protein crosslinking, and surface immobilization of biomolecules.

Application

• Antibody-Drug Conjugate (ADC) Linker: Used to covalently attach cytotoxic payloads to monoclonal antibodies via cysteine residues.
• Protein/Peptide Crosslinking: Enables the site-specific conjugation of proteins, peptides, or other thiol-containing molecules.
• Surface Functionalization: For modifying gold surfaces, nanoparticles, or biosensor chips with thiol-reactive maleimide groups.
• Polymer Modification: Acts as a crosslinker or functional end-group in the synthesis of hydrogels and smart polymers.
• Diagnostic Assay Development: Conjugation of enzymes, fluorophores, or haptens to carrier proteins or solid supports in immunoassays.
• Biomaterial Engineering: Creating bioactive scaffolds for tissue engineering by crosslinking thiolated biomolecules.

Basic Information

Product Name	1,11-Bis-Maleimidotetraethyleneglycol
CAS No.	86099-06-1
Molecular Formula	C20H28N2O10
Molecular Weight	456.45 g/mol
Synonyms	BM(PEG)4; 1,11-Bis(maleimido)-3,6,9-trioxaundecane; PEG4 bis-maleimide; Tetraethylene glycol bis-maleimide; Bis-Maleimido-PEG4; BM(PEG)4 Crosslinker; 1,11-Bis(maleimidotetraethyleneglycol); 3,6,9,12-Tetraoxatetradecanedioic acid bis(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl) ester
EINECS	Contact for details

Quality Control

Our 1,11-Bis-Maleimidotetraethyleneglycol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and bioconjugation applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be kept under desiccant or in an inert atmosphere for long-term storage to prevent hydrolysis of the maleimide groups. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.