Description

Fmoc-Trp-Opfp CAS NO 86069-87-6 is a high-purity, protected amino acid derivative specifically engineered for solid-phase peptide synthesis (SPPS). This compound serves as a critical building block, enabling the efficient and selective incorporation of tryptophan into complex peptide sequences. It is an essential reagent for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors developing therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): Primary reagent for the controlled, sequential addition of the tryptophan amino acid residue using Fmoc-chemistry protocols.
• Therapeutic Peptide Production: Key intermediate in the synthesis of peptide-based pharmaceuticals, including hormones, antimicrobial peptides, and targeted therapeutics.
• Combinatorial Chemistry Libraries: Used to create diverse peptide libraries for high-throughput screening in drug discovery and lead optimization.
• Bioconjugation and Probe Development: Acts as a precursor for synthesizing fluorescently labeled or otherwise modified peptides for imaging and diagnostic applications.
• Academic and Industrial Research: Fundamental tool for studying protein-protein interactions, enzyme specificity, and peptide structure-activity relationships (SAR).
• Custom Peptide Service Providers: Essential raw material for CROs and CDMOs offering bespoke peptide synthesis services to the global market.

Basic Information

Item	Detail
Product Name	Fmoc-Trp-Opfp
CAS No.	86069-87-6
Molecular Formula	C₃₁H₂₁F₅N₂O₅
Molecular Weight	596.51 g/mol
Synonyms	Fmoc-Tryptophan-OPfp ester; N-(9-Fluorenylmethoxycarbonyl)-L-tryptophan pentafluorophenyl ester; Fmoc-L-tryptophan pentafluorophenyl ester; Fmoc-Trp-OPfp; Fmoc-Trp-OPh(CF₃)₂; Nα-Fmoc-L-tryptophan pentafluorophenyl ester; (9H-Fluoren-9-yl)methyl (2S)-2-[(2-{[(pentafluorophenoxy)carbonyl]amino}ethyl)carbamoyl]-1H-indole-3-carboxylate
EINECS	Contact for details

Quality Control

Our Fmoc-Trp-Opfp is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, typically ≥98% (HPLC). Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and chiral analysis to verify enantiomeric purity. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., nitrogen or argon) due to its hygroscopic and light-sensitive nature. For short-term use, the material may be stored at 2-8°C for several days if kept in a sealed, desiccated environment. Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.