Description

Fmoc-Leu-Opfp CAS NO 86060-88-0 is a high-purity, protected amino acid derivative, specifically the pentafluorophenyl (Opfp) ester of Fmoc-Leucine. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling efficient and high-yield coupling reactions. It is primarily used by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers for the production of peptides, peptidomimetics, and other bioactive molecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key activated ester for the efficient incorporation of leucine residues into peptide chains.
• Pharmaceutical Research & Development: Synthesis of peptide-based drug candidates, hormones, and diagnostic agents.
• Combinatorial Chemistry: Used in the generation of diverse peptide libraries for screening biological activity.
• Bioconjugation: Facilitates the site-specific labeling or modification of peptides and proteins.
• Academic Research: Fundamental studies in peptide chemistry, biochemistry, and medicinal chemistry.
• Production of Custom Peptides: Essential reagent for CROs and CDMOs offering custom peptide synthesis services.

Basic Information

Product Name	Fmoc-Leu-Opfp
CAS No.	86060-88-0
Molecular Formula	C27H22F5NO4
Molecular Weight	519.46 g/mol
Synonyms	Fmoc-L-leucine pentafluorophenyl ester; N-(9-Fluorenylmethoxycarbonyl)-L-leucine pentafluorophenyl ester; Fmoc-Leu-OPfp; Fmoc-Leu-OPfp ester; (9H-Fluoren-9-yl)methyl (2S)-2-[(2-methylpropoxy)carbonylamino]-4-methylpentanoate; Fmoc-Leu-O-Pfp; Fmoc-L-Leu-OPfp; Nα-Fmoc-L-leucine pentafluorophenyl ester
EINECS	Contact for details

Quality Control

Our Fmoc-Leu-Opfp is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity, suitable for sensitive synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing key parameters such as purity (HPLC), chiral purity, and moisture content. Our quality management system is designed to meet the stringent requirements of GMP and ISO standards for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and reactivity. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 0.5%
Solubility	Soluble in DMF, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.