Description

Fmoc-Ala-Opfp is a high-purity, activated ester derivative of the amino acid alanine, protected with a 9-fluorenylmethoxycarbonyl (Fmoc) group. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the efficient and controlled formation of peptide bonds. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors who require reliable, high-quality reagents for producing peptides, peptidomimetics, and other complex biomolecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key reagent for the Fmoc-strategy of peptide chain elongation, specifically for incorporating alanine residues.
• Pharmaceutical Intermediates: Used in the research and development of novel therapeutic peptides and peptide-based drugs.
• Bioconjugation: Facilitates the site-specific labeling or modification of peptides and proteins with various probes or functional groups.
• Combinatorial Chemistry: Employed in the generation of peptide libraries for high-throughput screening in drug discovery.
• Academic & Industrial Research: A fundamental tool for studying protein structure-function relationships and biochemical pathways.
• Production of Custom Peptides: Used by CROs and CDMOs for the contract manufacturing of specific peptide sequences for clients.

Basic Information

Product Name	Fmoc-Ala-Opfp
CAS No.	86060-86-8
Molecular Formula	C25H16F5NO5
Molecular Weight	505.39 g/mol
Synonyms	Fmoc-L-alanine pentafluorophenyl ester; N-(9-Fluorenylmethoxycarbonyl)-L-alanine pentafluorophenyl ester; Fmoc-L-Ala-OPfp; Fmoc-Alanine-OPfp ester; N-α-Fmoc-L-alanine pentafluorophenyl ester; (9H-Fluoren-9-yl)methyl (2S)-2-[(pentafluorophenoxy)carbonylamino]propanoate; Fmoc-Ala-OPh(CF3)2 (common abbreviation)
EINECS	Contact for details

Quality Control

Our Fmoc-Ala-Opfp is manufactured under strict quality protocols to ensure batch-to-batch consistency and high chemical purity, suitable for demanding synthetic applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable to support our clients in regulated research and development environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C to -10°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and reactivity. Allow the container to reach room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.