Description

Fmoc-Gly-Opfp is a highly reactive, protected amino acid derivative used as a key building block in solid-phase peptide synthesis (SPPS). Its value lies in the pentafluorophenyl (Opfp) ester group, which acts as an efficient leaving group, enabling rapid and high-yielding coupling reactions under mild conditions. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors who require reliable, high-purity intermediates for the production of peptides, peptide mimetics, and other bioactive compounds.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a protected glycine derivative for the efficient, stepwise assembly of peptide chains on resin supports.
• Solution-Phase Peptide Synthesis: For fragment condensation or segment coupling strategies in solution, leveraging its high reactivity.
• Production of Pharmaceutical Intermediates: In the synthesis of active pharmaceutical ingredients (APIs) and investigational new drugs that contain glycine or require its incorporation.
• Bioconjugation and Labeling: For introducing glycine-based linkers or spacers into biomolecules like proteins, antibodies, or oligonucleotides.
• Combinatorial Chemistry: As a building block in the generation of diverse chemical libraries for drug discovery and screening.
• Academic and Industrial Research: For fundamental studies in organic chemistry, medicinal chemistry, and peptide science.

Basic Information

Item	Details
Product Name	Fmoc-Gly-Opfp
CAS No.	86060-85-7
Molecular Formula	C23H14F5NO4
Molecular Weight	463.36 g/mol
Synonyms	Fmoc-Glycine pentafluorophenyl ester; N-(9-Fluorenylmethoxycarbonyl)glycine pentafluorophenyl ester; N-Fmoc-glycine Opfp ester; Fmoc-Gly-OPfp; Fmoc-Glycine OPfp ester; Glycine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-, 2,3,4,5,6-pentafluorophenyl ester; (9H-Fluoren-9-ylmethoxy)carbonyl-glycine 2,3,4,5,6-pentafluorophenyl ester
EINECS	Contact for details

Quality Control

Our Fmoc-Gly-Opfp is manufactured under strict quality management systems to ensure batch-to-batch consistency and high chemical purity, suitable for demanding research and production applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and reactivity. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms to standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Solubility	Soluble in DMF, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.