Description

Amphimedine CAS NO 86047-14-5 is a bioactive marine alkaloid belonging to the pyridoacridine class, known for its unique pentacyclic structure. This compound is of significant interest in pharmaceutical research due to its potent biological activities, particularly its topoisomerase II inhibition and antitumor properties. It serves as a critical reference standard and a promising scaffold for medicinal chemists and researchers in oncology and infectious disease studies.

Application

• Pharmaceutical Research & Development: As a lead compound and reference standard in the discovery of novel anticancer and antimicrobial agents.
• Biochemical Studies: Used to investigate mechanisms of topoisomerase II inhibition and DNA intercalation.
• Medicinal Chemistry: Serves as a core structure for the synthesis of analogs to explore structure-activity relationships (SAR).
• Academic Research: Employed in university and institutional labs for studying marine natural products and their bioactivity.
• Contract Research Organizations (CROs): Utilized as a validated compound in high-throughput screening (HTS) assays for drug discovery programs.
• Biotech Applications: Potential use in developing targeted therapies and as a tool compound in cell-based assays.

Basic Information

Product Name	Amphimedine
CAS No.	86047-14-5
Molecular Formula	C17H11N3O2
Molecular Weight	289.29 g/mol
Synonyms	1H-Pyrido[4,3,2-de]quinolin-2(8H)-one, 7,8,9,10-tetrahydro-3-hydroxy-7-methyl-; Amphimedine; 3-Hydroxy-7-methyl-7,8,9,10-tetrahydro-1H-pyrido[4,3,2-de]quinolin-2(8H)-one; Marine alkaloid amphimedine; Pyridoacridine alkaloid
EINECS	Contact for details

Quality Control

Our Amphimedine is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification, NMR and MS for structural confirmation, and residual solvent analysis. We provide a comprehensive Certificate of Analysis (COA) with each shipment, detailing all test results to ensure compliance with your research specifications. Our quality commitment supports applications requiring high-purity reference standards.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and easily oxidized; prolonged exposure to air, light, or moisture should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	Yellow to orange powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.