Description

2',3'-Dideoxyguanosine 5'-Triphosphate is a modified nucleoside triphosphate analog, a critical building block in molecular biology and biochemistry research. Its primary value lies in its ability to act as a chain terminator in enzymatic DNA synthesis, making it indispensable for specific sequencing and diagnostic applications. This high-purity biochemical is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostic industries developing novel assays and therapeutic agents.

Application

• DNA Sequencing: Used as a substrate in Sanger sequencing and next-generation sequencing (NGS) platforms for specific termination reactions.
• Polymerase Chain Reaction (PCR): Employed in specialized PCR applications, including allele-specific amplification and mutagenesis studies.
• Enzymatic Synthesis: Serves as a modified nucleotide triphosphate (dNTP) for the in vitro synthesis of oligonucleotides with specific termination properties.
• Antiviral Research: Investigated as a potential metabolite or analog in the study of nucleoside reverse transcriptase inhibitors (NRTIs) for antiviral drug development.
• Biochemical Assays: Utilized as a substrate or inhibitor in enzymatic assays to study polymerase kinetics, fidelity, and mechanism.
• Diagnostic Kit Manufacturing: A key raw material in the production of diagnostic kits for genetic testing and pathogen detection.

Basic Information

Product Name	2',3'-Dideoxyguanosine 5'-Triphosphate
CAS No.	85956-71-4
Molecular Formula	C10H16N5O12P3
Molecular Weight	507.17 g/mol
Synonyms	ddGTP; 2',3'-Dideoxy-GTP; 2′,3′-Dideoxyguanosine-5′-triphosphate; Dideoxyguanosine triphosphate; 9-[(2R,3S,5R)-3-Hydroxy-5-(hydroxymethyl)oxolan-2-yl]-2-amino-6-oxo-1H-purin-3-ium-5-yl trihydrogen triphosphate
EINECS	Contact for details

Quality Control

Our 2',3'-Dideoxyguanosine 5'-Triphosphate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity assessment and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for sensitive life science research. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. Due to its hygroscopic (moisture-sensitive) nature, the product should be allowed to equilibrate to room temperature before opening to prevent condensation. For long-term storage, consider under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC/UV)	Conforms to reference standard
Purity (HPLC)	≥ 95% (Anhydrous basis)
Water Content (Karl Fischer)	≤ 5.0 %
pH (1% Solution)	6.0 - 8.0
Biological Activity	Suitable for use in enzymatic synthesis

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.