Description

n-Trimethyl-γ-Aminobutyric Acid-D9 Chloride is a high-purity, deuterium-labeled derivative of the neurotransmitter GABA (γ-aminobutyric acid). This stable isotope-labeled compound is essential for advanced analytical research, providing an internal standard for precise quantification in mass spectrometry. It is primarily used by researchers and manufacturers in the pharmaceutical, biotechnology, and analytical chemistry sectors for method development, pharmacokinetic studies, and metabolic research.

Application

• Internal Standard for LC-MS/MS: Serves as a critical deuterated internal standard for the accurate quantification of GABA and related metabolites in complex biological matrices like plasma, serum, and cerebrospinal fluid.
• Neuropharmacology Research: Used in studies investigating the GABAergic system, neurotransmitter dynamics, and the mechanisms of action for neuroactive drugs.
• Metabolomics and Biomarker Discovery: Enables precise tracking and measurement in metabolic pathway analysis for disease biomarker identification.
• Pharmaceutical Development: Supports drug metabolism and pharmacokinetics (DMPK) studies for candidate drugs targeting neurological disorders.
• Clinical Diagnostics: Facilitates the development of highly accurate clinical assays for neurological and metabolic conditions.
• Quality Control in API Manufacturing: Acts as a reference standard in the quality control of active pharmaceutical ingredients (APIs) that interact with GABA pathways.

Basic Information

Product Name	n-Trimethyl-γ-Aminobutyric Acid-D9 Chloride
CAS No.	85806-17-3
Molecular Formula	C₇H₅D₉ClNO₂
Molecular Weight	~188.71 g/mol (for unlabeled form, contact for exact D9 value)
Synonyms	GABA-trimethyl-d9 chloride; (3-Carboxypropyl)trimethylammonium-d9 chloride; 4-Aminobutyric acid trimethyl-d9 chloride; 4-Trimethylammonio-d9 butyrate chloride; 4-(N,N,N-Trimethyl-d9)aminobutyric acid chloride; TMGABA-d9 chloride; γ-Aminobutyric acid trimethyl-d9 chloride; Perdeuterated carnitine chloride derivative (structural analog)
EINECS	Contact for details

Quality Control

Our n-Trimethyl-γ-Aminobutyric Acid-D9 Chloride is manufactured under strict quality systems to ensure the highest isotopic purity and chemical integrity. Each batch is characterized by advanced analytical techniques including NMR (¹H, ¹³C), Mass Spectrometry, and HPLC to confirm isotopic enrichment (D9), chemical purity, and identity. A comprehensive Certificate of Analysis (COA) detailing assay, isotopic purity, and impurity profile is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccator after opening to maintain stability and purity. For long-term storage, consider storing at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Isotopic Purity (D9)	≥ 98 atom % D
Chemical Purity (NMR)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.