Description

3'-Fluoroaminopterin is a fluorinated derivative of the classic antifolate compound aminopterin, designed for enhanced biochemical research and development. This modified analog is valued for its potential to act as a potent inhibitor of dihydrofolate reductase (DHFR), offering researchers a tool with altered metabolic stability and binding affinity. It is primarily utilized by pharmaceutical R&D teams, academic biochemists, and contract research organizations (CROs) engaged in targeted cancer therapy development, enzyme inhibition studies, and structure-activity relationship (SAR) investigations.

Application

• Biochemical Research: Serves as a critical reference standard and active compound in enzymatic studies, particularly for investigating dihydrofolate reductase (DHFR) inhibition mechanisms.
• Anticancer Agent Development: Used in preclinical research for the synthesis and evaluation of novel chemotherapeutic agents targeting folate metabolism pathways.
• Pharmacology & Toxicology Studies: Employed in in vitro and in vivo models to study the efficacy, pharmacokinetics, and toxicological profiles of antifolate drugs.
• Academic Research: A key reagent for universities and institutes focusing on medicinal chemistry, cancer biology, and drug design projects.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting drug discovery pipelines that require high-purity, specialized chemical entities.

Basic Information

Product Name	3'-Fluoroaminopterin
CAS No.	85803-34-5
Molecular Formula	C19H20FN7O5
Molecular Weight	445.41 g/mol
Synonyms	3'-Fluoro-4-aminopteroylglutamate; 3'-F-Aminopterin; N-[4-[[(2,4-Diamino-6-pteridinyl)methyl](3-fluoro)amino]benzoyl]-L-glutamic Acid; 3-Fluoroaminopterin; 3'-Fluoro-4-aminofolic Acid; 3'-F-AMT; Aminopterin, 3'-fluoro- derivative
EINECS	Contact for details

Quality Control

Every batch of 3'-Fluoroaminopterin is manufactured and tested under strict quality management systems to ensure identity, purity, and consistency. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, detailing key parameters such as assay purity and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This material is light-sensitive (store away from light). For long-term storage, consider conditions of 2-8°C. Keep the container tightly sealed in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥95.0%
Water Content (KF)	≤2.0%
Residue on Ignition	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.