Description

2'-Fluoroaminopterin is a fluorinated derivative of the classic antifolate compound aminopterin, designed to enhance biochemical stability and target specificity. This modification is critical for advanced research in oncology and biochemistry, where precise molecular tools are required to study folate metabolism and enzyme inhibition. It serves as a key intermediate and research chemical for pharmaceutical development, particularly in the synthesis of novel chemotherapeutic agents and targeted therapies. Researchers and developers in the life sciences sector rely on this high-purity compound for its defined activity in probing biological pathways.

Application

• Pharmaceutical Research & Development: As a potent dihydrofolate reductase (DHFR) inhibitor, it is used in the study of antifolate mechanisms and the development of new anticancer drugs.
• Biochemical Assay Standard: Serves as a reference standard in enzymatic assays to quantify DHFR activity and screen for potential inhibitors.
• Academic Research: Utilized in university and institutional labs for fundamental studies on cell proliferation, nucleotide synthesis, and targeted cancer therapy.
• Precision Medicine Studies: Investigated for its potential in personalized treatment regimens, especially in cancers with specific metabolic profiles.
• Chemical Synthesis Intermediate: Acts as a specialized building block for the synthesis of more complex fluorinated antifolate analogs.
• Cell Culture & Toxicology Studies: Employed in *in vitro* models to induce folate deficiency and study its effects on cell growth and viability.

Basic Information

Product Name	2'-Fluoroaminopterin
CAS No.	85803-29-8
Molecular Formula	C19H20FN7O5
Molecular Weight	445.41 g/mol
Synonyms	2'-Fluoro-4-aminopteroylglutamate; 2'-F-Aminopterin; N-[4-[[(2-Amino-4-hydroxy-6-pteridinyl)methyl](2-fluoro)amino]benzoyl]-L-glutamic Acid; 2-Fluoroaminopterin; FA; 2'-Fluoro-4-aminofolic acid; 2'-Fluoro-APA; (2-Fluoro)aminopterin
EINECS	Contact for details

Quality Control

Every batch of 2'-Fluoroaminopterin is manufactured under strict quality management protocols to ensure identity, purity, and consistency. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with research-grade standards. A comprehensive Certificate of Analysis (COA), detailing purity, assay results, and impurity profiles, is provided with each shipment and is available upon request to support your quality assurance processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere conditions.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.