Description

Fos-Choline-13, Sol-Grade is a high-purity, synthetic phospholipid analog specifically designed for solubilization applications. This specialized grade is critical for creating stable, clear solutions of membrane proteins and other challenging biomolecules in biochemical research. It is an essential reagent for structural biology, drug discovery, and biophysical studies where maintaining native protein conformation is paramount. Researchers and production facilities in the pharmaceutical and life science sectors rely on its consistent performance for reproducible results.

Application

• Membrane Protein Solubilization & Stabilization: Primary use for extracting and stabilizing integral membrane proteins (e.g., GPCRs, ion channels, transporters) from cell membranes for functional and structural analysis.
• Biophysical & Structural Studies: Essential for preparing samples for techniques like X-ray crystallography, cryo-electron microscopy (cryo-EM), and nuclear magnetic resonance (NMR) spectroscopy.
• Drug Discovery Screening: Used to create native-like lipid environments for in vitro assays targeting membrane-bound receptors and enzymes, improving hit validation.
• Liposome & Nanodisc Formation: Acts as a key component in constructing model membrane systems, such as proteoliposomes and membrane scaffold protein (MSP) nanodiscs.
• Cell Biology Research: Employed in studies of lipid-protein interactions, membrane dynamics, and cellular signaling pathways.

Basic Information

Product Name	Fos-Choline-13, Sol-Grade
CAS No.	85775-42-4
Molecular Formula	C18H40NO4P
Molecular Weight	365.49 g/mol
Synonyms	FOS-Choline-13; Foscholine-13; 1-Tridecanoyl-2-hydroxy-sn-glycero-3-phosphocholine; Lyso PC(13:0); 1-Myristoyl-2-hydroxy-sn-glycero-3-phosphocholine (common name for C13:0 chain); L-α-Lysophosphatidylcholine (C13:0); 1-Tridecanoyl-sn-glycero-3-phosphocholine; 2-Hydroxy-1-tridecanoyl-sn-glycero-3-phosphocholine
EINECS	Contact for details

Quality Control

Our Fos-Choline-13, Sol-Grade is manufactured under strict quality systems to ensure the high purity and consistency required for sensitive research applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and critical impurity profiles. We adhere to cGMP guidelines for production and control, ensuring traceability and reliability for our global B2B clients in the life sciences.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). For long-term storage, keep under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid or waxy solid
Identification (IR / NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Lyso PC Content (HPLC)	≥ 95.0% (of total phospholipid)
Solubility (in water/buffer)	Forms clear, colorless solution at 1-5% (w/v)
Critical Micelle Concentration (CMC)	Typically 0.1 - 0.5 mM (Contact for batch-specific data)
Heavy Metals (as Pb)	≤ 10 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.