Description

6'-n-4-Azidobenzyltobramycin is a chemically modified derivative of the aminoglycoside antibiotic tobramycin, featuring a strategically introduced azidobenzyl group at the 6'-n position. This functionalization is critical for its primary role as a key intermediate in advanced bioconjugation and chemical biology research, enabling the development of novel probes and targeted therapeutic agents. It is an essential building block for pharmaceutical R&D scientists and biotech companies focused on antibiotic derivatization, activity-based protein profiling, and the synthesis of site-specifically labeled biomolecules.

Application

• Bioconjugation & Probe Development: Serves as a versatile intermediate for attaching tobramycin to other molecules (e.g., fluorophores, affinity tags, solid supports) via click chemistry or other bioorthogonal reactions.
• Chemical Biology Research: Used in activity-based protein profiling (ABPP) to study aminoglycoside interactions, resistance mechanisms, and cellular targets.
• Antibiotic Derivative Synthesis: A crucial precursor for creating novel tobramycin analogs with potentially enhanced properties or altered modes of action.
• Pharmaceutical R&D: Employed in the discovery and development of next-generation targeted antimicrobial therapies and diagnostic tools.
• Academic Research: Utilized in universities and research institutes for fundamental studies on antibiotic function and bacterial cell wall synthesis.

Basic Information

Product Name	6'-n-4-Azidobenzyltobramycin
CAS No.	85733-85-3
Molecular Formula	C29H47N9O12
Molecular Weight	689.74 g/mol
Synonyms	4-Azidobenzyl-6'-n-tobramycin; Tobramycin, 6'-N-(4-azidobenzyl)-; 6'-N-(4-Azidobenzyl)tobramycin; 6'-Deoxy-6'-(4-azidobenzylamino)tobramycin; 6'-Azidobenzylamido-tobramycin; Azidobenzyl-tobramycin conjugate; Tobramycin azidobenzyl derivative; Antibiotic intermediate 85733-85-3
EINECS	Contact for details

Quality Control

Our 6'-n-4-Azidobenzyltobramycin is produced under controlled conditions to ensure high chemical purity and batch-to-batch consistency, suitable for sensitive research applications. Each batch undergoes rigorous analytical characterization, including HPLC for purity assessment and spectroscopic methods (NMR, MS) for structural confirmation. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions when possible. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.