Description

Dexamethasone-Biotin Labelled is a high-purity, biotin-conjugated derivative of the potent synthetic glucocorticoid dexamethasone. This compound is specifically engineered for advanced research applications, combining the anti-inflammatory and immunosuppressive activity of dexamethasone with the high-affinity binding properties of biotin. It is an essential tool for scientists in pharmaceutical R&D, biochemistry, and molecular biology who require precise detection and isolation mechanisms. The product is supplied under stringent quality controls to ensure batch-to-batch consistency and reliable performance in sensitive assays.

Application

• Biochemical Research & Assay Development: Used as a critical reagent in the development of ELISA, Western blot, and other immunoassays for detecting glucocorticoid receptor activity.
• Drug Discovery & Pharmacology: Serves as a molecular probe in high-throughput screening (HTS) and binding studies to identify and characterize new therapeutic agents targeting the glucocorticoid receptor.
• Molecular Imaging & Diagnostics: Facilitates the study of receptor localization and trafficking within cells when paired with streptavidin-conjugated fluorophores or enzymes.
• Affinity Purification & Pull-Down Assays: Enables the isolation and purification of glucocorticoid receptor proteins and associated complexes from biological samples using streptavidin-coated beads.
• Cellular & Molecular Biology Studies: Employed to investigate steroid hormone signaling pathways, gene expression regulation, and cellular stress responses.

Basic Information

Product Name	Dexamethasone-Biotin Labelled
CAS No.	85679-56-7
Molecular Formula	C36H49FO9S
Molecular Weight	676.84 g/mol
Synonyms	Biotinylated Dexamethasone; Dexamethasone-Biotin Conjugate; Dexamethasone Biotin Labeled; 9-Fluoro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione 21-hemisuccinate-biotin conjugate; Biotin-Dexamethasone; Dexamethasone linked to Biotin; Dexamethasone-Hemisuccinate-Biotin; Glucocorticoid Receptor Probe-Biotin
EINECS	Contact for details

Quality Control

Our Dexamethasone-Biotin Labelled is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and stability. Each batch is validated using advanced techniques including HPLC, mass spectrometry, and NMR to confirm structural integrity and conjugation efficiency. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis. For long-term stability, store under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.