Description

5,8-Dideazaisopteroyl Triglutamate is a high-purity, non-classical antifolate compound of significant interest in biochemical and pharmaceutical research. This molecule matters for its role as a potent inhibitor of key folate-dependent enzymes, offering a valuable tool for studying cellular metabolism and therapeutic pathways. It is primarily needed by research institutions and pharmaceutical developers focused on oncology, infectious diseases, and metabolic disorder research, where precise biochemical probes are essential for discovery and validation.

Application

• Biochemical Research: Used as a specific inhibitor in enzymatic studies targeting folate metabolism pathways, including thymidylate synthase and dihydrofolate reductase.
• Oncology Research: Serves as a key reference compound and biochemical tool in the investigation of novel anticancer agents and mechanisms of drug resistance.
• Antimicrobial Agent Development: Investigated for its potential inhibitory effects on microbial folate synthesis, relevant for developing new anti-infective therapies.
• Metabolic Pathway Analysis: Employed in cell-based assays to modulate intracellular folate pools and study the effects on nucleotide synthesis and cell proliferation.
• Pharmaceutical Reference Standard: Utilized as a high-purity analytical standard for method development, validation, and quality control in drug discovery and development.
• Academic Research: A critical reagent for universities and research institutes conducting fundamental studies in enzymology, medicinal chemistry, and molecular pharmacology.

Basic Information

Product Name	5,8-Dideazaisopteroyl Triglutamate
CAS No.	85344-30-5
Molecular Formula	C30H35N7O11
Molecular Weight	669.64 g/mol
Synonyms	5,8-Dideaza-5,6,7,8-tetrahydroisopteroyl triglutamate; DDATHF Triglutamate; Lometrexol Triglutamate (related analog); Non-classical Antifolate Triglutamate; 5,8-Dideazatetrahydroisopteroyl Triglutamate; PT523 (common research code); Glutamate-conjugated Antifolate
EINECS	Contact for details

Quality Control

Our 5,8-Dideazaisopteroyl Triglutamate is manufactured under strict quality systems to ensure batch-to-batch consistency and reliability for critical research applications. Each lot undergoes comprehensive analytical characterization, including purity verification by HPLC and structural confirmation. A Certificate of Analysis (COA) detailing all test results is provided with every shipment, ensuring full traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant use and storage under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.