Description

Methylprednisolone Ethylothopropionate is a synthetic corticosteroid ester prodrug, designed for enhanced lipophilicity and targeted therapeutic action. This compound is critical for pharmaceutical manufacturers requiring precise and potent anti-inflammatory agents in advanced drug formulations. It serves as a key active pharmaceutical ingredient (API) and intermediate for research and production in the steroid hormone sector, meeting the stringent demands of the global pharmaceutical industry.

Application

• Pharmaceutical API: Primary use as an active pharmaceutical ingredient in injectable or topical corticosteroid formulations.
• Anti-inflammatory Medications: Formulation of potent medications for treating severe allergic reactions, dermatological conditions, and rheumatic disorders.
• Prodrug Development: Utilized in the development of prodrugs for improved dermal penetration or sustained-release profiles.
• Veterinary Pharmaceuticals: Component in anti-inflammatory and immunosuppressive treatments for animals.
• Research & Development: Critical reference standard and intermediate in steroid chemistry and pharmacological research.
• Dermatological Preparations: Used in creams and ointments for treating psoriasis, eczema, and other skin inflammations.

Basic Information

Product Name	Methylprednisolone Ethylothopropionate
CAS No.	85198-27-2
Molecular Formula	C27H38O6
Molecular Weight	458.59 g/mol
Synonyms	Methylprednisolone 17-Ethylcarbonate 21-Propionate; Methylprednisolone 17α-Ethylcarbonate-21-propionate; 6α-Methylprednisolone 17-Ethylcarbonate 21-Propionate; Methylprednisolone Ethyl Carbonate Propionate; U-8471; Depo-Medrate; Medrate; Medrol ester; Corticosteroid ester prodrug
EINECS	Contact for details

Quality Control

Our Methylprednisolone Ethylothopropionate is manufactured under strict quality management systems, targeting compliance with pharmaceutical-grade standards. Each batch undergoes comprehensive analytical testing including HPLC for assay and related substances, residual solvent analysis, and identity confirmation. A Certificate of Analysis (COA) documenting purity, impurities, and physical characteristics is provided with every shipment to ensure traceability and regulatory support.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.