Description

Dicesium n-Succinimidyl 3-(Undecahydrododecaboranyldithio)Propionate is a specialized cesium salt derivative of a boron cluster-containing active ester. This compound is engineered for high-value conjugation chemistry, offering a unique combination of a cleavable disulfide linker and a highly reactive N-hydroxysuccinimide (NHS) ester group. It is critical for researchers and manufacturers requiring precise, stable, and reversible attachment of boron-rich clusters to biomolecules, peptides, or other functional materials. Primary demand originates from advanced fields such as boron neutron capture therapy (BNCT) research, pharmaceutical development, and the synthesis of sophisticated diagnostic and therapeutic agents.

Application

• Boron Neutron Capture Therapy (BNCT) Agents: Serves as a key intermediate for synthesizing tumor-targeting boron delivery compounds, enabling the reversible attachment of undecahydrododecaborate clusters to antibodies, peptides, or other targeting moieties.
• Bioconjugation & Protein Labeling: The NHS ester group facilitates efficient amide bond formation with primary amines on proteins, antibodies, or peptides, while the disulfide bond allows for controlled release under reducing conditions.
• Diagnostic Probe Development: Used in the construction of advanced imaging probes where a cleavable linker is beneficial, particularly in multimodal imaging applications.
• Polymer & Material Science: Functionalization of polymers, nanoparticles, or surfaces with boron clusters for specialized applications in catalysis, neutron shielding, or drug delivery systems.
• Pharmaceutical Intermediate: Acts as a critical building block in the multi-step synthesis of novel therapeutic candidates, especially those leveraging boron chemistry.
• Research & Development: A valuable tool in academic and industrial R&D for exploring new boron-based chemistries and bioconjugation strategies.

Basic Information

Product Name	Dicesium n-Succinimidyl 3-(Undecahydrododecaboranyldithio)Propionate
CAS No.	85070-11-7
Molecular Formula	C15H24B12Cs2N2O4S2
Molecular Weight	Contact for details
Synonyms	Dicesium NHS-SS-undecahydrododecaborate; Cesium 3-((2,5-dioxopyrrolidin-1-yl)oxy)-3-oxopropyl undecahydrododecaborate(2-) disulfide; Cesium salt of N-succinimidyl 3-(dodecahydrododecaborate(2-)disulfanyl)propanoate; BSH-NHS ester cesium salt; Dicesium [3-(2,5-dioxo-1-pyrrolidinyloxy)-3-oxopropyl]disulfanyl-dodecahydrododecaborate(2-); NHS-SS-B12H11SH Cs salt
EINECS	Contact for details

Quality Control

Our Dicesium n-Succinimidyl 3-(Undecahydrododecaboranyldithio)Propionate is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and assay, NMR for structural confirmation, and mass spectrometry. We provide full traceability and documentation. Certificates of Analysis (COA) detailing all specifications and test results are available upon request and accompany every shipment to ensure compliance with your research and development protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) in a desiccated environment. This compound is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture condensation. For long-term stability, store in the original sealed packaging.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Assay (NMR/Titration)	≥ 90%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMF, DMSO; slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.