Description

6'-o-Dansyl-γ-Aminobutyryl Atractyloside is a specialized, fluorescently labeled derivative of atractyloside, a potent and specific inhibitor of the mitochondrial adenine nucleotide translocator (ANT). This compound is engineered for advanced research applications, combining the biological activity of atractyloside with the dansyl fluorophore for detection and visualization. It is primarily utilized by researchers in biochemistry, pharmacology, and cell biology studying mitochondrial function, apoptosis, and energy metabolism. The product offers a critical tool for probing nucleotide transport mechanisms and cellular bioenergetics in vitro.

Application

• Mitochondrial Research: As a fluorescent probe to study the function and inhibition of the Adenine Nucleotide Translocator (ANT) in isolated mitochondria or permeabilized cells.
• Apoptosis Studies: Investigation of the role of the mitochondrial permeability transition pore (MPTP) in programmed cell death pathways.
• Biochemical Assay Development: Used in the development of high-throughput screening (HTS) assays or binding studies to identify novel modulators of mitochondrial transport.
• Cellular Imaging: Fluorescent labeling and tracking of ANT in fixed cell preparations, utilizing the dansyl moiety for microscopy.
• Mechanistic Pharmacology: Tool compound for elucidating the mechanisms of drugs or toxins that affect mitochondrial energy metabolism.
• Reference Standard: Serves as an analytical standard for quality control and method validation in research and development settings.

Basic Information

Product Name	6'-o-Dansyl-γ-Aminobutyryl Atractyloside
CAS No.	84872-88-8
Molecular Formula	C48H61N3O16S
Molecular Weight	968.1 g/mol
Synonyms	Dansyl-Atractyloside; Dansyl-GABA-Atractyloside; 6'-O-[5-(Dimethylamino)naphthalene-1-sulfonyl]-γ-aminobutyryl Atractyloside; Fluorescent Atractyloside; Atractyloside Dansyl Derivative; ANT Fluorescent Inhibitor; Atractyloside, 6'-O-[N-[4-[(5-dimethylamino-1-naphthalenyl)sulfonyl]amino]butyryl]-
EINECS	Contact for details

Quality Control

Our 6'-o-Dansyl-γ-Aminobutyryl Atractyloside is manufactured under controlled conditions to ensure high purity and batch-to-batch consistency suitable for research applications. Quality is verified through a comprehensive suite of analytical techniques including HPLC, NMR, and mass spectrometry. A detailed Certificate of Analysis (COA) providing purity, identity confirmation, and impurity profile is supplied with each batch to support your experimental integrity and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is both light-sensitive and hygroscopic. Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	Yellow to orange solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.