Description

Fmoc-Trp-Osu CAS NO 84771-20-0 is a high-purity, activated ester derivative of the amino acid tryptophan, protected with a 9-fluorenylmethoxycarbonyl (Fmoc) group. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the efficient and controlled incorporation of tryptophan into peptide chains. It is essential for researchers and manufacturers in pharmaceutical development, biotechnology, and academic research focused on creating novel therapeutic peptides, peptidomimetics, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): Primary reagent for the automated, stepwise synthesis of peptides containing tryptophan residues.
• Pharmaceutical R&D: Key intermediate in the development of peptide-based drugs, hormones, and diagnostic agents.
• Combinatorial Chemistry: Used in libraries for high-throughput screening to discover new bioactive compounds.
• Bioconjugation: Facilitates the site-specific labeling of proteins, antibodies, or other biomolecules with tryptophan-linked tags or probes.
• Academic Research: Fundamental tool for studying protein structure-function relationships, enzyme substrates, and receptor ligands.
• Production of Custom Peptides: Used by CROs and CDMOs for the reliable and scalable manufacture of bespoke peptides for clients.

Basic Information

Product Name	Fmoc-Trp-Osu
CAS No.	84771-20-0
Molecular Formula	C29H24N2O6
Molecular Weight	496.51 g/mol
Synonyms	N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-tryptophan N-hydroxysuccinimide ester; Fmoc-L-tryptophan N-succinimidyl ester; Fmoc-L-Trp-OSu; Fmoc-Tryptophan-OSu; Nα-Fmoc-Nin-Boc-L-tryptophan active ester; Nα-(9-Fluorenylmethyloxycarbonyl)-L-tryptophan N-hydroxysuccinimide ester; Fmoc-Trp-OSu ester; Fmoc-Trp-ONSu
EINECS	Contact for details

Quality Control

Our Fmoc-Trp-Osu is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for sensitive synthetic applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for fine chemicals and peptide synthesis reagents.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the sealed container to equilibrate to room temperature before opening to minimize moisture condensation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	-15.0° to -20.0° (c=1 in DMF)
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMF, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.