Description

5'-o-Thymidyl 3'-o-Thymidylphosphate is a chemically synthesized dinucleoside monophosphate, a key building block in oligonucleotide synthesis. This compound is essential for research and development in the fields of molecular biology, diagnostics, and therapeutic oligonucleotide manufacturing. It is primarily utilized by pharmaceutical R&D departments, biotechnology companies, and academic research institutions focused on antisense technology, siRNA, and aptamer development.

Application

• Oligonucleotide Synthesis: Serves as a critical phosphoramidite precursor or intermediate in the solid-phase synthesis of DNA and RNA sequences.
• Therapeutic Development: Used in the research and production of antisense oligonucleotides, siRNA, and other nucleic acid-based therapeutics.
• Diagnostic Probes: Acts as a component in the manufacture of labeled probes for genetic testing, PCR, and hybridization assays.
• Biochemical Research: Employed as a substrate or standard in enzymatic studies involving nucleotidyl transferases, polymerases, and phosphorylases.
• Pharmaceutical Intermediates: Functions as a high-purity intermediate in the synthesis of more complex nucleotide analogs and prodrugs.

Basic Information

Product Name	5'-o-Thymidyl 3'-o-Thymidylphosphate
CAS No.	84332-64-9
Molecular Formula	C21H27N4O15P
Molecular Weight	606.43 g/mol
Synonyms	Thymidylyl(3'→5')thymidine phosphate; TpT; Thymidyl(3'-5')thymidine phosphate; 5'-O-Thymidylyl-(3'→5')-thymidine 3'-phosphate; d(TpT); Thymidine 5'-(3-thymidylate); 3'-Thymidylic acid, 5'-ester with thymidine; Dinucleoside monophosphate TpT
EINECS	Contact for details

Quality Control

Our 5'-o-Thymidyl 3'-o-Thymidylphosphate is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency, suitable for sensitive research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable, and specifications can be aligned with customer requirements for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider desiccated conditions at -20°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.