Description

Dipalmitoylglycerophospho-n-((n-(1-Oxyl-2,2,6,6-Tetramethyl-4-Piperidinyl)Carbamoyl)Methyl)Ethanolamine is a specialized phospholipid derivative containing a stable nitroxide radical (TEMPO) moiety, making it a powerful spin-labeling agent for biophysical research. This compound is critical for studying membrane dynamics, protein-lipid interactions, and oxidative processes within lipid bilayers. It is primarily utilized by research institutions, pharmaceutical R&D departments, and advanced material scientists focused on membrane biophysics and radical chemistry.

Application

• Spin-Labeling in Membrane Biophysics: As a paramagnetic probe for Electron Paramagnetic Resonance (EPR) spectroscopy to investigate lipid bilayer fluidity, phase transitions, and domain formation.
• Protein-Lipid Interaction Studies: Used to map the binding sites and conformational changes of membrane-associated proteins and peptides.
• Model Membrane Systems: Incorporation into liposomes and supported lipid bilayers to create well-defined systems for studying oxidation kinetics and radical scavenging at membrane interfaces.
• Antioxidant Research: Serving as a synthetic, membrane-localized radical to study the efficacy and mechanisms of lipophilic antioxidants.
• Drug Delivery Research: Functional component in the design of advanced liposomal carriers where tracking and stability assessment are required.
• Material Science: Used in the development of smart surfaces and sensors that respond to redox changes or radical species.

Basic Information

Product Name	Dipalmitoylglycerophospho-n-((n-(1-Oxyl-2,2,6,6-Tetramethyl-4-Piperidinyl)Carbamoyl)Methyl)Ethanolamine
CAS No.	83993-19-5
Molecular Formula	C49H96N3O9P
Molecular Weight	918.27 g/mol
Synonyms	1,2-Dipalmitoyl-sn-glycero-3-phospho(TEMPO-methyl-carbamoylethanolamine); 16:0 TEMPO-PE; TEMPO-labeled DPPE; DPPE-TEMPO; 1,2-Dihexadecanoyl-sn-glycero-3-phosphoethanolamine-N-[4-[(2,2,6,6-tetramethyl-1-oxylpiperidin-4-yl)carbamoyl]methyl]; Phosphatidylethanolamine, N-[(4-[(carboxymethyl)amino]-2,2,6,6-tetramethyl-1-piperidinyl)oxy]-, 1,2-dihexadecanoyl; Spin-labeled DPPE
EINECS	Contact for details

Quality Control

Our Dipalmitoylglycerophospho-n-((n-(1-Oxyl-2,2,6,6-Tetramethyl-4-Piperidinyl)Carbamoyl)Methyl)Ethanolamine is manufactured under strict quality protocols to ensure high purity and batch-to-batch consistency suitable for sensitive research applications. Each lot is characterized by advanced analytical techniques including NMR, mass spectrometry, and HPLC to verify structural integrity and radical content. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and specific tests is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (argon or nitrogen) to minimize oxidation. Allow the sealed container to reach room temperature before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	Yellow to orange waxy solid or film
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Assay (EPR)	≥ 90% radical content
Solubility	Soluble in chloroform, methanol, DMSO; forms vesicles in aqueous buffer

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.