Description

n-α-(4-Amino-4-Deoxy-N(10)-Methylpteroyl)-N(Delta)-(5-(N,n-Dimethylamino)-1-Naphthalenesulfonyl)Ornithine is a sophisticated, high-purity biochemical reagent designed for advanced research and development. This compound is critical for applications requiring precise molecular interaction, particularly in the study of enzyme inhibition and targeted therapeutic mechanisms. It is primarily utilized by pharmaceutical R&D teams, diagnostic kit manufacturers, and academic research institutions focused on oncology and metabolic pathways.

Application

• Pharmaceutical Research & Development: Serves as a key intermediate or reference standard in the development of novel antifolate and chemotherapeutic agents.
• Biochemical Assay Development: Used as a specialized substrate or inhibitor in enzymatic assays, particularly for studying dihydrofolate reductase (DHFR) and related enzymes.
• Diagnostic Reagent Manufacturing: Incorporated into high-sensitivity diagnostic kits for clinical testing and biomarker detection.
• Academic & Life Science Research: A vital tool for investigating folate metabolism, cell signaling pathways, and mechanism-of-action studies in cancer biology.
• Proteomics & Molecular Labeling: Utilized in protein conjugation and labeling techniques due to its dansyl (Dns) fluorophore component, enabling fluorescence-based detection.
• Quality Control & Reference Standards: Acts as an analytical reference standard for method validation and purity assessment in QC laboratories.

Basic Information

Product Name	n-α-(4-Amino-4-Deoxy-N(10)-Methylpteroyl)-N(Delta)-(5-(N,n-Dimethylamino)-1-Naphthalenesulfonyl)Ornithine
CAS No.	83966-27-2
Molecular Formula	C₃₃H₄₀N₁₀O₇S
Molecular Weight	720.81 g/mol
Synonyms	Dansyl-Methotrexate-Ornithine Conjugate; Dns-MTX-Orn; N-Dansyl-N'-methotrexate ornithine; 5-(Dimethylamino)naphthalene-1-sulfonyl-methotrexate-ornithine; MTX-Dns-Ornithine; Fluorescent Methotrexate Derivative; Antifolate-Dansyl Conjugate; L-Ornithine, N2-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-N5-[[5-(dimethylamino)-1-naphthalenyl]sulfonyl]-
EINECS	Contact for details

Quality Control

Our n-α-(4-Amino-4-Deoxy-N(10)-Methylpteroyl)-N(Delta)-(5-(N,n-Dimethylamino)-1-Naphthalenesulfonyl)Ornithine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This compound is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, consider desiccant and under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	Yellow to orange solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.