Description

2-Isobutyl-Platelet Activating Factor is a synthetic analog of the potent phospholipid mediator, Platelet Activating Factor (PAF), characterized by its specific isobutyl substitution. This compound is a critical research tool for studying PAF receptor signaling pathways, inflammation, and immune responses in biological systems. It is essential for pharmaceutical R&D, academic research, and biochemical studies focused on cardiovascular, respiratory, and inflammatory diseases.

Application

• Biochemical Research: A key reference standard and agonist for investigating PAF receptor (PAFR) biology, signal transduction, and cellular activation mechanisms.
• Pharmaceutical Development: Used in high-throughput screening (HTS) assays to identify and validate novel PAF receptor antagonists and anti-inflammatory drug candidates.
• Inflammation Studies: Employed in vitro and in vivo models to induce and study inflammatory cascades, leukocyte activation, and vascular permeability.
• Immunology Research: Serves as a tool to probe the role of lipid mediators in immune cell communication, allergic responses, and anaphylaxis.
• Academic & Clinical Research: Fundamental for university labs and clinical research organizations exploring the pathophysiology of sepsis, asthma, and atherosclerosis.
• Diagnostic Reagent Manufacturing: Can be utilized in the development of specialized diagnostic kits and assay components for research purposes.

Basic Information

Product Name	2-Isobutyl-Platelet Activating Factor
CAS No.	83922-30-9
Molecular Formula	C26H54NO7P
Molecular Weight	523.68 g/mol
Synonyms	2-Isobutyl-PAF; 1-O-Octadecyl-2-O-isobutyl-sn-glycero-3-phosphocholine; Isobutyl-PAF C-16; PAF C-16 Isobutyl Analog; Platelet Activating Factor (2-Isobutyl); sn-Glycero-3-phosphocholine, 1-O-octadecyl-2-O-(2-methylpropyl)-; 1-O-Octadecyl-2-O-(2-methylpropyl)-sn-glycero-3-phosphocholine
EINECS	Contact for details

Quality Control

Our 2-Isobutyl-Platelet Activating Factor is manufactured under stringent conditions to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot undergoes comprehensive analytical characterization, including HPLC, NMR, and MS, to confirm identity and purity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. For long-term storage, solutions should be prepared in appropriate anhydrous solvents and kept at -80°C. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid or waxy solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in chloroform, ethanol, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.