Description

N,n-Dimethylthiomuscimol CAS NO 83913-02-4 is a synthetic thiomuscinol derivative, a potent and selective agonist for GABA receptors. This compound is of significant value in advanced neuroscience and pharmacological research, serving as a critical tool for studying receptor subtypes and neurochemical pathways. It is primarily needed by research institutions, pharmaceutical R&D departments, and chemical suppliers focused on developing and screening novel neuroactive compounds and therapeutic agents.

Application

• Neuroscience Research: As a selective GABAA receptor agonist for investigating inhibitory neurotransmission, receptor binding, and channel physiology.
• Pharmacological Studies: Used in vitro and in vivo to study the effects of GABAergic system modulation, aiding in the understanding of related neurological conditions.
• Drug Discovery & Development: A key reference standard and bioactive scaffold in high-throughput screening (HTS) campaigns for identifying new central nervous system (CNS) therapeutics.
• Biochemical Assay Development: Employed in the development and validation of assays targeting GABA receptor activity and signal transduction pathways.
• Chemical Synthesis Intermediate: Serves as a specialized building block for the synthesis of more complex neuroactive molecules and labeled analogs for tracer studies.

Basic Information

Product Name	N,n-Dimethylthiomuscimol
CAS No.	83913-02-4
Molecular Formula	C7H12N2O2S
Molecular Weight	188.25 g/mol
Synonyms	5-(Dimethylamino)-4,5-dihydroisoxazol-3-ol Thioamide; 3-Hydroxy-5-(dimethylamino)-4,5-dihydroisoxazole-3-thiocarboxamide; Thiomuscinol, N,N-dimethyl-; DM-Thiomuscinol; GABAA receptor agonist (thiomuscinol derivative); 4,5-Dihydro-5-(dimethylamino)-3-isoxazolethiol; (RS)-5-(Dimethylamino)-4,5-dihydro-1,2-oxazole-3-thiocarboxamide
EINECS	Contact for details

Quality Control

Our N,n-Dimethylthiomuscimol is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes comprehensive analytical characterization, including identity confirmation by spectroscopic methods (NMR, IR, MS) and purity assessment by chromatographic techniques (HPLC). A Certificate of Analysis (COA) detailing all relevant specifications is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. For long-term storage, consider keeping the material under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.