Description

20-Carboxy-Leukotriene B4 CAS NO 83861-61-4 is a key metabolite and analytical standard of the potent inflammatory mediator Leukotriene B4 (LTB4). This compound is essential for researchers and developers in the life sciences, providing a critical tool for studying eicosanoid metabolism, inflammation pathways, and related disease mechanisms. It is primarily used by pharmaceutical R&D teams, diagnostic manufacturers, and academic institutions focused on immunology, respiratory diseases, and biomarker discovery.

Application

• Biochemical Research Standard: Serves as a primary reference standard for the quantification of LTB4 metabolites in biological samples via LC-MS/MS or ELISA.
• Inflammation & Immunology Studies: Used to investigate the role of leukotriene metabolism in inflammatory processes, neutrophil activation, and immune response modulation.
• Pharmaceutical Development: Critical for the development and validation of assays screening for inhibitors of the LTB4 pathway in drug discovery programs.
• Diagnostic Kit Manufacturing: Employed as a calibrator or control in the production of immunoassay kits for clinical and research use.
• Metabolomics & Biomarker Discovery: A vital analyte in profiling eicosanoids to identify biomarkers for diseases like asthma, arthritis, and psoriasis.
• Quality Control: Used as an internal standard in analytical laboratories to ensure accuracy and precision in leukotriene analysis.

Basic Information

Product Name	20-Carboxy-Leukotriene B4
CAS No.	83861-61-4
Molecular Formula	C₂₀H₃₂O₅
Molecular Weight	352.47 g/mol
Synonyms	20-COOH-LTB4; 20-Carboxy-LTB4; 5(S),12(R)-Dihydroxy-6,8,10,14-eicosatetraenoic-1,20-dioic Acid; Leukotriene B4 20-Carboxylic Acid; ω-Carboxy-Leukotriene B4; 20-COOH-5(S),12(R)-dihydroxy-6Z,8E,10E,14Z-eicosatetraenoic Acid; LTB4 20-COOH
EINECS	Contact for details

Quality Control

Our 20-Carboxy-Leukotriene B4 is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, MS), to ensure it meets the high standards required for research and diagnostic applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay results, and chromatographic data is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive) and easily oxidized; therefore, it must be handled in a dry environment and sealed under vacuum or nitrogen after each use to ensure long-term stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥95%
Water Content (KF)	≤1.0%
Solubility	Soluble in ethanol, DMSO; slightly soluble in aqueous buffer

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.