Description

n-Pentafluorobenzoylmethionylglycine-n-Hydroxysuccinimide Ester CAS NO 83800-45-7 is a specialized, high-purity active ester derivative used as a critical reagent in advanced bioconjugation and peptide synthesis. Its core value lies in its high reactivity with primary amines, enabling efficient and selective labeling of biomolecules for research and diagnostic applications. This compound is essential for pharmaceutical R&D, proteomics, and the development of novel antibody-drug conjugates (ADCs) and diagnostic assays.

Application

• Bioconjugation Reagent: For the site-specific labeling of proteins, antibodies, and peptides with fluorophores, tags, or other functional molecules.
• Antibody-Drug Conjugate (ADC) Development: As a key linker-payload intermediate for attaching cytotoxic drugs to monoclonal antibodies.
• Proteomics & Biomarker Research: Used in chemical proteomics for activity-based protein profiling (ABPP) and target identification.
• Diagnostic Assay Manufacturing: In the production of enzyme-linked immunosorbent assay (ELISA) kits and other immunoassays.
• Peptide Synthesis: As an activated ester for coupling in solid-phase peptide synthesis (SPPS), particularly for challenging sequences.
• Material Science: For the surface functionalization of nanoparticles and polymers to create bioactive materials.

Basic Information

Product Name	n-Pentafluorobenzoylmethionylglycine-n-Hydroxysuccinimide Ester
CAS No.	83800-45-7
Molecular Formula	C19H18F5N3O6S
Molecular Weight	511.42 g/mol
Synonyms	PFB-Met-Gly-OSu; Pentafluorobenzoyl-Methionyl-Glycine N-Hydroxysuccinimide Ester; N-Succinimidyl Pentafluorobenzoylmethionylglycinate; 2,5-Dioxopyrrolidin-1-yl (2S)-2-[(2S)-2-[(2,3,4,5,6-pentafluorobenzoyl)amino]-4-(methylsulfanyl)butanamido]acetate; NSC 339586; Methionine-Glycine NHS Ester Pentafluorobenzoyl Derivative; Active Ester of Pentafluorobenzoylmethionylglycine
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch is characterized using advanced analytical techniques, including HPLC, NMR, and mass spectrometry, to guarantee identity, purity, and consistency. Certificates of Analysis (COA) with detailed chromatographic data are available upon request. We adhere to cGMP guidelines for the manufacture of critical pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant in a freezer. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMF, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.