Description

12-Epi Leukotriene B4 is a bioactive eicosanoid and a stereoisomer of the potent inflammatory mediator Leukotriene B4 (LTB4). This compound is of significant value as a critical reference standard and research tool in biochemical and pharmacological studies. It is primarily needed by researchers and analytical laboratories in the pharmaceutical, biotechnology, and academic sectors for investigating inflammatory pathways, receptor binding studies, and as a calibration standard in mass spectrometry.

Application

• Biochemical Research: Used as a precise reference standard in studies of the 5-lipoxygenase pathway and eicosanoid biosynthesis.
• Pharmacological Studies: Essential for investigating the biological activity, receptor affinity, and metabolic fate of leukotriene analogs.
• Analytical Standard: Serves as a high-purity calibrant for quantitative analysis via HPLC, LC-MS, and other chromatographic techniques.
• Inflammation Research: A key tool for modeling inflammatory processes and screening potential anti-inflammatory drug candidates.
• Cell Signaling Studies: Used to elucidate the role of specific leukotriene isomers in cellular signaling and immune response.

Basic Information

Product Name	12-Epi Leukotriene B4
CAS No.	83709-73-3
Molecular Formula	C₂₀H₃₂O₄
Molecular Weight	336.47 g/mol
Synonyms	(5S,12R)-Dihydroxy-(6Z,8E,10E,14Z)-eicosatetraenoic Acid; 12-epi-LTB4; 12R-Hydroxy-5S,14Z-eicosatetraenoic Acid; Leukotriene B4 Epimer; 12-epi-Leukotriene B4; LTB4 Epimer; 12R-LTB4
EINECS	Contact for details

Quality Control

Every batch of 12-Epi Leukotriene B4 is manufactured and analyzed under strict quality management protocols to ensure identity, purity, and consistency. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, assay, and chromatographic profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95%
Assay	≥ 98% (by titration)
Solubility	Soluble in ethanol, DMSO; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.