Description

3-(4-(n-Biotinoyl-6-Aminocaproyloxy)Phenyl)Propionic Acid is a specialized biotin derivative featuring a cleavable linker arm. This compound is engineered to facilitate the biotinylation of biomolecules, enabling their subsequent capture, detection, or purification via the high-affinity streptavidin-biotin interaction. It is an essential reagent for researchers and manufacturers in the life sciences sector, particularly those developing diagnostic assays, targeted drug delivery systems, and advanced bioconjugation platforms. The extended 6-aminocaproyl spacer enhances accessibility and reduces steric hindrance in binding applications.

Application

• Bioconjugation Reagent: For the site-specific labeling of antibodies, peptides, proteins, and oligonucleotides with biotin.
• Diagnostic Assay Development: A key component in the production of ELISA kits, lateral flow tests, and other immunoassays that utilize streptavidin-biotin signal amplification.
• Affinity Chromatography: Used to synthesize ligands for immobilizing streptavidin/avidin on solid supports to purify biotin-tagged molecules.
• Drug Delivery & Targeting: Incorporated into biotin-drug conjugates or nanoparticle formulations for targeted therapeutic applications.
• Cell Surface Labeling: For tagging membrane proteins or receptors on live cells for flow cytometry or microscopy studies.
• Proteomics & Protein Interaction Studies: Employed in pull-down assays to isolate and identify protein complexes.
• Material Science: Functionalization of surfaces and nanomaterials for biosensor development and biointerface engineering.

Basic Information

Product Name	3-(4-(n-Biotinoyl-6-Aminocaproyloxy)Phenyl)Propionic Acid
CAS No.	83592-10-3
Molecular Formula	C25H35N3O6S
Molecular Weight	505.63 g/mol
Synonyms	Biotin-XX-SSE; Biotinamidocaproyl-4-hydroxy-3-phenylpropionic acid; N-Biotinyl-6-aminocaproic acid 4-hydroxy-3-phenylpropionic acid ester; Biotin-LC-Phenylpropionate; Biotin-XX, SE; (+)-Biotinyl-6-aminocaproic acid N-hydroxysuccinimide ester; EZ-Link™ Biotin-XX-SSE; Biotin (long chain) NHS ester
EINECS	Contact for details

Quality Control

Our 3-(4-(n-Biotinoyl-6-Aminocaproyloxy)Phenyl)Propionic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (NMR, IR), to ensure it meets the high standards required for sensitive life science applications. Certificates of Analysis (COA) detailing all specifications and test results are provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a dry environment before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in DMSO, DMF; slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.