Description

2,3,6,7-Tetrahydroxycholanoic Acid is a high-purity, polyhydroxylated bile acid derivative with significant research and development potential. This compound is valued for its specific structural configuration, which makes it a critical intermediate in the synthesis of novel pharmaceutical agents and biochemical probes. It is primarily sought by research institutions and pharmaceutical companies engaged in metabolic pathway studies, hepatology research, and the development of targeted therapeutic molecules.

Application

• Pharmaceutical Intermediate: Serves as a key chiral building block in the synthesis of advanced drug candidates targeting liver and metabolic diseases.
• Biochemical Research: Used as a reference standard or probe in studies of bile acid metabolism, receptor binding, and transporter function.
• Metabolite Standard: Employed in analytical laboratories for method development and calibration in LC-MS/MS analysis of complex biological samples.
• Enzyme Substrate/Analogue: Investigated for its interaction with specific enzymes involved in steroid and bile acid biosynthesis pathways.
• Precursor for Conjugates: Acts as a starting material for the synthesis of glycine or taurine-conjugated bile acid analogues for specialized research applications.

Basic Information

Product Name	2,3,6,7-Tetrahydroxycholanoic Acid
CAS No.	83504-21-6
Molecular Formula	C₂₄H₄₀O₆
Molecular Weight	424.57 g/mol
Synonyms	3α,6α,7α,12α-Tetrahydroxy-5β-cholan-24-oic Acid; Tetrahydroxycholanoic Acid; 5β-Cholan-24-oic acid, 3,6,7,12-tetrahydroxy-, (3α,5β,6α,7α,12α)-; 2,3,6,7-Tetrahydroxy-5β-cholan-24-oic Acid; 3,6,7,12-Tetrahydroxycholanoic Acid
EINECS	Contact for details

Quality Control

Our 2,3,6,7-Tetrahydroxycholanoic Acid is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing including HPLC for purity, NMR and IR for structural confirmation, and specific tests for residual solvents and moisture. We provide full traceability and a detailed Certificate of Analysis (COA) with every shipment to ensure compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.