Description

Leucyl-Leucyl-4-Azido-2-Nitrophenylalanine is a specialized, custom-designed peptide derivative that serves as a critical building block in advanced biochemical research and development. Its core value lies in its unique functional groups, which enable its use as a versatile cross-linking agent and a photoactivatable probe for studying protein-protein interactions and biomolecular labeling. This compound is essential for researchers and developers in the fields of chemical biology, proteomics, and pharmaceutical discovery who require high-purity, well-characterized synthetic intermediates for creating novel diagnostic tools and therapeutic agents.

Application

• Photoaffinity Labeling (PAL): Acts as a key reagent in PAL studies to capture transient or weak biomolecular interactions for target identification and validation.
• Bioconjugation & Cross-linking: Used to create stable covalent bonds between peptides, proteins, or other biomolecules for constructing complex molecular architectures.
• Proteomics Research: Employed in the development of activity-based probes (ABPs) to profile enzyme activities within complex biological samples.
• Drug Discovery Platforms: Serves as a specialized intermediate in the synthesis of peptide-drug conjugates (PDCs) and targeted therapeutics.
• Material Science & Surface Functionalization: Applied to modify surfaces with bioactive peptides for creating advanced biosensors and biomaterials.
• Chemical Biology Tool Development: Integral for designing novel chemical tools to investigate cellular pathways and mechanisms of action.

Basic Information

Product Name	Leucyl-Leucyl-4-Azido-2-Nitrophenylalanine
CAS No.	83447-91-0
Molecular Formula	C24H35N7O6
Molecular Weight	517.58 g/mol
Synonyms	LL-ANP; Leu-Leu-ANP; N-(4-Azido-2-nitrophenyl)-L-leucyl-L-leucine; 4-Azido-2-nitrophenylalanine-Leu-Leu derivative; ANP-Leu-Leu; Photo-Leucine-Leucine analog; L-Leucyl-L-leucyl-4-azido-2-nitro-L-phenylalanine; Custom Photoactivatable Dipeptide
EINECS	Contact for details

Quality Control

Every batch of Leucyl-Leucyl-4-Azido-2-Nitrophenylalanine is synthesized and purified under controlled conditions to meet the exacting standards of research and development. Our quality assurance protocol includes comprehensive analytical characterization to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing results from HPLC, MS, and NMR are provided with each shipment to support your regulatory and documentation requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, inert environment. This compound is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed vial to equilibrate to room temperature before opening to minimize condensation and moisture uptake.

Specification

Item	Specification
Appearance	Yellow to orange powder or solid
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.