Description

2-Pyridyldithioethylmethylamidodiethoxyethane Methylaminomethyltrimethylpsoralen is a specialized heterocyclic organic compound that functions as a critical bifunctional linker and photoreactive agent. Its molecular architecture, combining a psoralen moiety with a cleavable dithiopyridyl linker, is engineered for advanced bioconjugation and cross-linking applications. This product is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly in the development of targeted drug delivery systems, photoaffinity labeling, and the synthesis of antibody-drug conjugates (ADCs).

Application

• Bioconjugation Reagent: Used as a heterobifunctional cross-linker for coupling biomolecules like proteins, peptides, and oligonucleotides, facilitating the creation of stable or cleavable conjugates.
• Antibody-Drug Conjugate (ADC) Synthesis: Serves as a key intermediate in constructing linker-payload complexes, where the psoralen group can be utilized for photo-crosslinking or the dithiopyridyl group for controlled drug release.
• Photoaffinity Labeling: The trimethylpsoralen moiety allows for covalent cross-linking to nucleic acids or proteins upon UV irradiation, a vital tool for studying biomolecular interactions and mapping binding sites.
• Prodrug Development: Enables the design of stimuli-responsive prodrugs where the linker is cleaved under specific biological conditions (e.g., in the presence of reducing agents like glutathione).
• Surface Functionalization: Applied to modify nanoparticles, chips, or other solid supports with bioactive molecules for biosensing, diagnostics, and material science applications.
• Chemical Biology Research: A valuable tool for probing enzyme mechanisms, protein-protein interactions, and cellular pathways due to its dual reactive groups.

Basic Information

Item	Details
Product Name	2-Pyridyldithioethylmethylamidodiethoxyethane Methylaminomethyltrimethylpsoralen
CAS No.	83353-04-2
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	2-Pyridyldithioethylmethylamidodiethoxyethane Methylaminomethyltrimethylpsoralen; Psoralen-PDPH; Methylaminomethyltrimethylpsoralen-PDP; Heterobifunctional Psoralen Linker; PDP-Psoralen Crosslinker; Photoactivatable PDP Reagent; 4'-Aminomethyl-4,5',8-trimethylpsoralen PDP derivative; SPDP-Psoralen analog
EINECS	Contact for details

Quality Control

Every batch of 2-Pyridyldithioethylmethylamidodiethoxyethane Methylaminomethyltrimethylpsoralen undergoes rigorous analytical testing to ensure identity, purity, and consistency suitable for research and development applications. Our quality assurance protocols are designed to meet the stringent requirements of chemical biology and pharmaceutical intermediates. A comprehensive Certificate of Analysis (COA), detailing purity by HPLC, identity confirmation by spectroscopic methods, and impurity profiles, is provided with each shipment to support your quality and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This compound is light-sensitive (store away from light) and should be handled under inert atmosphere when appropriate to maintain stability. Keep the container sealed in a desiccator if long-term storage is required to minimize exposure to moisture.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content	≤ 1.0%
Residual Solvents	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.