Description

5-Phosphopyridoxal-Aminooxyacetate is a high-purity biochemical reagent, a phosphorylated derivative of pyridoxal (vitamin B6) conjugated with aminooxyacetate. This compound is a critical tool compound and intermediate in biochemical research, particularly valued for its role as a potent inhibitor of aminotransferase enzymes. It is essential for researchers and manufacturers in the pharmaceutical, diagnostic, and life science sectors who require precise enzyme modulation for drug discovery, metabolic pathway studies, and diagnostic assay development.

Application

• Biochemical Research: Used as a specific, potent inhibitor of pyridoxal phosphate-dependent enzymes, particularly aminotransferases like GABA transaminase, for studying neurotransmitter metabolism and amino acid pathways.
• Pharmaceutical Development: Serves as a key intermediate or reference standard in the synthesis and development of novel therapeutic agents targeting neurological disorders and metabolic diseases.
• Diagnostic Reagent Manufacturing: Employed in the formulation of enzymatic assay kits for clinical diagnostics, where precise enzyme inhibition is required for accurate metabolite measurement.
• Enzymology Studies: A vital tool for in vitro and in vivo studies to elucidate the mechanism of action of vitamin B6-dependent enzymes and to validate drug targets.
• Metabolomics & Proteomics: Used in research to perturb specific metabolic networks, enabling the mapping of biochemical fluxes and protein functions.

Basic Information

Product Name	5-Phosphopyridoxal-Aminooxyacetate
CAS No.	83351-95-5
Molecular Formula	C13H17N2O9P
Molecular Weight	376.26 g/mol
Synonyms	PLP-AOA; Pyridoxal 5'-Phosphate Aminooxyacetate; 5'-O-Phosphonopyridoxal Aminooxyacetate; Aminooxyacetic Acid Pyridoxal Phosphate Ester; Vitamin B6 Phosphate Aminooxyacetate; AOA-PLP; (4-Formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate aminooxyacetate
EINECS	Contact for details

Quality Control

Every batch of 5-Phosphopyridoxal-Aminooxyacetate is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure identity, purity, and consistency, meeting the stringent requirements of research and development. A Certificate of Analysis (COA) detailing specifications such as HPLC purity, NMR identification, and residual solvent content is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.