Description

Thiazole-4-Carboxamide Adenine Dinucleotide is a specialized biochemical cofactor and a key derivative of nicotinamide adenine dinucleotide (NAD+). This compound is of significant interest in biochemical research and pharmaceutical development due to its role as a substrate analog and potential modulator of NAD+-dependent enzymes. It is primarily utilized by research institutions, pharmaceutical R&D departments, and biotechnology companies engaged in enzymology, metabolic pathway studies, and the development of novel therapeutic agents.

Application

• Biochemical Research: Used as a substrate analog in studies of NAD+-dependent enzymes, including dehydrogenases, sirtuins, and poly(ADP-ribose) polymerases (PARPs).
• Pharmaceutical Development: Serves as a key intermediate or reference standard in the research and development of novel therapeutics targeting metabolic disorders and age-related diseases.
• Enzyme Mechanism Studies: Employed to investigate enzyme kinetics, inhibition, and cofactor binding specificity in academic and industrial research settings.
• Diagnostic Reagent Formulation: May be incorporated into specialized diagnostic kits and assay systems for clinical research and biomarker detection.
• Metabolic Pathway Analysis: A valuable tool for probing cellular metabolism, redox states, and energy production pathways in cell biology.

Basic Information

Product Name	Thiazole-4-Carboxamide Adenine Dinucleotide
CAS No.	83285-83-0
Molecular Formula	C₂₁H₂₇N₇O₁₄P₂S
Molecular Weight	695.49 g/mol
Synonyms	TAD; Thiazole-4-carboxamide adenine dinucleotide; 4-Thiazolecarboxamide, N-(5-O-[5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methylphosphonato)-β-D-ribofuranosyl)oxolan-2-yl)methyl dihydrogen diphosphate; NAD+ thiazole analog; Nicotinamide adenine dinucleotide thiazole derivative
EINECS	Contact for details

Quality Control

Our Thiazole-4-Carboxamide Adenine Dinucleotide is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent controls for moisture and related substances. A Certificate of Analysis (COA) detailing purity, identity, and specific test results is provided with every shipment to ensure traceability and compliance with your research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. Due to its hygroscopic (moisture-sensitive) nature, the container should be allowed to equilibrate to room temperature before opening to minimize moisture uptake. For long-term storage, consider desiccant or under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Individual impurity ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.