Description

L-Serine-Ul-14C is a uniformly carbon-14 labeled isotopologue of the essential amino acid L-Serine, identified by CAS NO 83245-14-1. This radiolabeled compound is a critical tool for researchers requiring precise metabolic and pharmacokinetic tracing in biological systems. It is indispensable for scientists in pharmaceutical development, biochemistry, and nutritional research who need to study serine's metabolic pathways, protein synthesis, and drug incorporation with high specificity and sensitivity.

Application

• Metabolic Pathway Tracing: Used as a radiotracer to elucidate the biosynthesis and catabolism of serine, glycine, and one-carbon units in cell culture and animal studies.
• Drug Metabolism and Pharmacokinetics (DMPK): Essential for labeling candidate drug molecules to study their absorption, distribution, metabolism, and excretion (ADME) profiles.
• Protein Turnover Studies: Incorporated into proteins to measure synthesis and degradation rates in metabolic research.
• Biochemical Research: Serves as a precursor in studies of phospholipid synthesis, nucleotide metabolism, and neurotransmitter production.
• Diagnostic Agent Development: Potential use in the research and development of novel Positron Emission Tomography (PET) imaging probes.

Basic Information

Product Name	L-Serine-Ul-14C
CAS No.	83245-14-1
Molecular Formula	C14₃H₇NO₃ * (specific labeled positions may vary)
Molecular Weight	~107.1 g/mol (exact value depends on specific activity)
Synonyms	(2S)-2-Amino-3-hydroxypropanoic acid (U-14C); L-Serine (U-14C); Serine (U-14C); (S)-Serine-U-14C; 14C-Serine; Uniformly Labeled Carbon-14 L-Serine; Radiolabeled L-Serine
EINECS	Contact for details

Quality Control

Every batch of L-Serine-Ul-14C is manufactured and analyzed under strict quality systems to ensure identity, purity, and specific activity. Our products undergo rigorous quality testing, including radiochemical purity analysis by HPLC and TLC, to ensure compliance with research standards. Certificates of Analysis (COA) detailing specific activity, radiochemical purity, chemical purity, and solvent composition are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep the container sealed under an inert atmosphere in a dedicated freezer. Always follow local radiation safety regulations for handling and storage.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR/HPLC)	Conforms to reference standard
Radiochemical Purity (HPLC)	≥ 97%
Chemical Purity (HPLC)	≥ 98%
Specific Activity	Customizable (e.g., 50-60 mCi/mmol)
Solvent (if supplied in solution)	Specified in COA (e.g., Ethanol:Water)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.