Description

Quin 2 is a high-purity, cell-permeable fluorescent calcium indicator widely used in biochemical and physiological research. Its core value lies in its high selectivity for calcium ions (Ca²⁺) over magnesium ions (Mg²⁺), enabling precise measurement of intracellular calcium concentrations. This compound is essential for researchers in life sciences, pharmacology, and cell biology studying calcium signaling pathways, cellular excitability, and related disease mechanisms.

Application

• Intracellular Calcium Imaging: Primary use as a fluorescent probe for real-time visualization and quantification of cytosolic free Ca²⁺ in live cells.
• Signal Transduction Research: Investigating the role of calcium as a second messenger in cellular processes like muscle contraction, neurotransmitter release, and gene expression.
• Pharmacological Screening: Used in high-throughput assays to evaluate drug effects on calcium channel activity and intracellular calcium homeostasis.
• Neuroscience Studies: Monitoring neuronal calcium dynamics to understand synaptic plasticity, neural development, and excitotoxicity.
• Cardiovascular Research: Studying calcium handling in cardiomyocytes, which is critical for understanding cardiac contractility and arrhythmias.
• Cell Viability & Apoptosis Assays: Employed in assays measuring calcium flux as an indicator of cell health and programmed cell death.

Basic Information

Product Name	Quin 2
CAS No.	83014-44-2
Molecular Formula	C₂₄H₂₄N₂O₁₂
Molecular Weight	532.46 g/mol
Synonyms	Quin-2; Quin2; 2-{[2-Bis(carboxymethyl)amino-5-methylphenoxy]methyl}-6-methoxy-8-bis(carboxymethyl)aminoquinoline; 2-{[2-[Bis(2-hydroxy-2-oxoethyl)amino]-5-methylphenoxy]methyl}-6-methoxy-8-[bis(2-hydroxy-2-oxoethyl)amino]quinoline; Quin-2 AM (acetoxymethyl ester precursor); Calcium indicator Quin-2; 1,2-Bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid analog (related compound).
EINECS	Contact for details

Quality Control

Our Quin 2 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high performance in sensitive research applications. Each lot undergoes rigorous analytical testing, including HPLC for purity verification and spectroscopic analysis for functional validation. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and assay results is provided with every shipment to support your research documentation and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and light-sensitive; ensure the container is sealed tightly after each use to minimize exposure to atmospheric moisture and light.

Specification

Item	Specification
Appearance	Yellow to light brown powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 3.0%
Fluorescence Properties	Conforms to reference (λex/λem ~ 339/492 nm, Ca²⁺ bound)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.