Description

Trimetrexate Glucuronate is a water-soluble glucuronate salt of the dihydrofolate reductase (DHFR) inhibitor trimetrexate. This compound is of significant interest in pharmaceutical research and development, particularly for its potential as a chemotherapeutic agent. It is primarily utilized by researchers and manufacturers in the pharmaceutical and biotechnology sectors for the synthesis of active pharmaceutical ingredients (APIs) and in preclinical studies.

Application

• Pharmaceutical Intermediate: Key starting material or intermediate in the synthesis of advanced chemotherapeutic agents and other therapeutic compounds.
• Biochemical Research: Used as a potent inhibitor of dihydrofolate reductase (DHFR) in enzymatic studies and metabolic pathway research.
• Antifolate Agent Development: Serves as a reference standard and active component in the development of novel antifolate drugs targeting cancer and opportunistic infections.
• Analytical Standard: Employed as a high-purity reference standard in HPLC, LC-MS, and other analytical methods for quality control and method validation.
• Preclinical Studies: Utilized in in vitro and in vivo studies to investigate efficacy, pharmacokinetics, and toxicity profiles.

Basic Information

Product Name	Trimetrexate Glucuronate
CAS No.	82952-64-5
Molecular Formula	C₂₆H₃₃N₅O₉
Molecular Weight	559.57 g/mol
Synonyms	Trimetrexate D-glucuronate; 2,4-Diamino-5-methyl-6-[(3,4,5-trimethoxyanilino)methyl]quinazoline glucuronate; TMQ glucuronate; NSC 352122 glucuronate; Trimetrexate glucuronate salt; 5-Methyl-6-[(3,4,5-trimethoxyphenyl)amino]methyl-2,4-quinazolinediamine glucuronate
EINECS	Contact for details

Quality Control

Our Trimetrexate Glucuronate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR, and residual solvent analysis, to ensure it meets the stringent requirements for research and pharmaceutical use. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤5.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.