Description

8-(4-Aminobutyl) Aminoadenosine-3',5'-Cyclic Monophosphate is a chemically modified derivative of cyclic adenosine monophosphate (cAMP), a crucial secondary messenger in cellular signaling. This compound is engineered with an extended aminobutyl side chain, enhancing its membrane permeability and stability for advanced biochemical research. It is primarily utilized by pharmaceutical R&D teams and academic researchers in life sciences for studying cell signaling pathways, enzyme regulation, and as a potential tool compound in drug discovery.

Application

• Biochemical Research: Used as a cell-permeable, hydrolysis-resistant analog of cAMP to study intracellular signal transduction mechanisms.
• Pharmaceutical Development: Serves as a key intermediate or reference standard in the development of drugs targeting protein kinase A (PKA) and other cAMP-dependent pathways.
• Cell Biology Studies: Applied in experiments to investigate the role of cAMP in processes like metabolism, gene expression, and ion channel function.
• Enzyme Assays: Acts as a substrate or modulator in assays for phosphodiesterases (PDEs) and adenylate cyclase activity.
• Neuroscience Research: Utilized to explore cAMP-mediated signaling in neuronal function, plasticity, and related disorders.
• Reference Standard: Employed as a high-purity analytical standard for quality control and method validation in analytical laboratories.

Basic Information

Product Name	8-(4-Aminobutyl) Aminoadenosine-3',5'-Cyclic Monophosphate
CAS No.	82927-68-2
Molecular Formula	C₁₄H₂₂N₈O₆P
Molecular Weight	429.35 g/mol
Synonyms	8-(4-Aminobutylamino)-cAMP; 8-(4-Aminobutyl)amino-cAMP; N⁶,2'-O-Dibutyryl-cAMP (related analog); 8-AHA-cAMP; 8-(4-Aminobutyl)adenosine cyclic 3',5'-monophosphate; cAMP, 8-(4-aminobutyl)amino-; 8-(4-Aminobutylamino)adenosine 3',5'-cyclic monophosphate; Bt₂cAMP derivative
EINECS	Contact for details

Quality Control

Our 8-(4-Aminobutyl) Aminoadenosine-3',5'-Cyclic Monophosphate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade specifications. Custom purity grades and analytical packages are available to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. Due to its hygroscopic nature, the product should be handled under anhydrous conditions and allowed to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Solvent Residues (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.