Description

16,17-Dihydro-17-Hydroxyrifamycin S is a key semi-synthetic derivative and a crucial intermediate in the synthesis of advanced rifamycin antibiotics. This compound matters significantly for its role in developing potent antimicrobial agents with improved pharmacological profiles. Pharmaceutical R&D laboratories and fine chemical manufacturers need it for producing next-generation antibiotics targeting resistant bacterial strains.

Application

• Pharmaceutical Intermediate: Primary use in the synthesis of advanced rifamycin-class antibiotics, such as Rifaximin and Rifampicin derivatives.
• Antimicrobial Research: Serves as a critical building block in medicinal chemistry for developing novel antibacterial agents.
• Bulk Drug Substance Manufacturing: Used in the commercial-scale production of active pharmaceutical ingredients (APIs) for anti-infective medications.
• Biochemical Research: Employed in studies investigating the structure-activity relationship (SAR) of ansamycin antibiotics.
• Reference Standard: Utilized as a high-purity analytical standard for quality control and regulatory testing in pharmaceutical labs.

Basic Information

Product Name	16,17-Dihydro-17-Hydroxyrifamycin S
CAS No.	82534-57-4
Molecular Formula	C37H47NO13
Molecular Weight	713.77 g/mol
Synonyms	17-Hydroxy-16,17-dihydrorifamycin S; 16,17-Dihydro-17-hydroxy-rifamycin S; Rifamycin S, 16,17-dihydro-17-hydroxy-; (17S)-16,17-Dihydro-17-hydroxyrifamycin S; L 105; Antibiotic L 105; Rifamycin Derivative L105; 17-Hydroxydihydrorifamycin S
EINECS	Contact for details

Quality Control

Our 16,17-Dihydro-17-Hydroxyrifamycin S is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical intermediate applications. A comprehensive Certificate of Analysis (COA) detailing purity, related substances, and residual solvents is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	Reddish-brown to orange powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Loss on Drying	≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.