Description

25-Desacetyl Rifampicin is a key pharmaceutical intermediate and metabolite of the important antibiotic rifampicin. This compound is of significant value in the research and development of novel anti-tuberculosis agents and for pharmacokinetic studies. It is primarily utilized by pharmaceutical manufacturers, contract research organizations (CROs), and academic institutions engaged in antibiotic development and analytical chemistry.

Application

• Pharmaceutical Intermediate: Critical synthesis building block for the development of new rifamycin-class antibiotics and derivatives.
• Metabolite Reference Standard: Used as an analytical standard in bioanalytical studies to quantify rifampicin metabolism in biological samples.
• Pharmacokinetic Research: Essential for studying the absorption, distribution, metabolism, and excretion (ADME) profile of rifampicin.
• Impurity Standard: Serves as a certified reference material (CRM) for quality control and impurity profiling of rifampicin active pharmaceutical ingredients (APIs).
• Biochemical Research: Used in studies investigating bacterial RNA polymerase inhibition and mechanisms of antibiotic action.

Basic Information

Product Name	25-Desacetyl Rifampicin
CAS No.	16783-99-6
Molecular Formula	C42H58N4O11
Molecular Weight	794.93 g/mol
Synonyms	25-Deacetylrifampicin; 25-Desacetylrifampicin; 3-[[(4-Methyl-1-piperazinyl)imino]methyl]rifamycin; Rifampicin Desacetyl; N-Desacetylrifampicin; Rifamycin Derivative; Rifampin Metabolite; Antibiotic Metabolite
EINECS	Contact for details

Quality Control

Our 25-Desacetyl Rifampicin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and MS, and residual solvent analysis, to ensure it meets the stringent requirements for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) to minimize oxidation. The container should be kept in a cool, dry, and well-ventilated area.

Specification

Item	Specification
Appearance	Reddish-brown to orange crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.