Description

21-o-Acetylstreptovaricinoic Acid Methyl Ester is a chemically modified derivative of the streptovaricin complex, a group of ansamycin antibiotics. This specific esterified compound is a crucial advanced intermediate in pharmaceutical research and development, particularly for the synthesis of novel therapeutic agents. It is primarily utilized by research institutions and pharmaceutical companies engaged in antibiotic discovery, medicinal chemistry, and the study of microbial biosynthesis pathways.

Application

• Pharmaceutical Intermediate: Key building block in the synthetic pathway for novel ansamycin-class antibiotics and anti-tuberculosis agents.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to develop derivatives with improved efficacy and reduced toxicity.
• Biochemical Research: Serves as a reference standard or probe in studies investigating the mode of action of RNA polymerase inhibitors.
• Microbiology Studies: Employed in research focused on combating drug-resistant bacterial strains, particularly Mycobacterium tuberculosis.
• Process Development: Used in scaling up and optimizing synthetic routes for complex natural product derivatives in pilot-scale manufacturing.

Basic Information

Product Name	21-o-Acetylstreptovaricinoic Acid Methyl Ester
CAS No.	11031-82-6
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	21-O-Acetylstreptovaricinoic Acid Methyl Ester; Methyl 21-O-Acetylstreptovarate; Streptovaricin C Methyl Ester, 21-O-Acetyl-; 21-O-Acetylstreptovaricinic Acid Methyl Ester; Ansamycin Derivative; Antibiotic G 418 Derivative
EINECS	Contact for details

Quality Control

Our 21-o-Acetylstreptovaricinoic Acid Methyl Ester is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity assessment and spectroscopic methods (NMR, MS) for structural confirmation. A detailed Certificate of Analysis (COA) documenting identity, purity, and related substances is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric moisture. For long-term storage, consider desiccant or inert atmosphere conditions.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.