Description

Rifampicin CAS NO 13292-46-1 is a semisynthetic, broad-spectrum antibiotic belonging to the ansamycin class, derived from *Amycolatopsis rifamycinica*. It is a cornerstone therapeutic agent in the global fight against tuberculosis (TB) and other mycobacterial infections. This product is essential for pharmaceutical manufacturers, research institutions, and compounding facilities developing anti-tuberculosis regimens and other antimicrobial therapies.

Application

• First-line Tuberculosis Treatment: A critical component of multi-drug regimens (e.g., with isoniazid, pyrazinamide, and ethambutol) for active TB.
• Leprosy (Hansen's Disease) Therapy: Used in combination with other agents like dapsone and clofazimine.
• Prophylaxis for Meningococcal Carriers: Used to eliminate *Neisseria meningitidis* from the nasopharynx of asymptomatic carriers.
• Prosthetic Device Infections: Incorporated into bone cement and other materials for the prevention and treatment of infections associated with orthopedic implants.
• Veterinary Medicine: Treatment of bacterial infections in animals, including staphylococcal infections.
• Biochemical Research: Used as a selective agent in molecular biology and microbiology research, particularly for its action on bacterial RNA polymerase.
• Pharmaceutical Intermediates: Serves as a starting material for the synthesis of more complex rifamycin derivatives.

Basic Information

Product Name	Rifampicin
CAS No.	13292-46-1
Molecular Formula	C43H58N4O12
Molecular Weight	822.94 g/mol
Synonyms	Rifampin; Rifamycin AMP; Rifadin; Rimactane; 3-[[(4-Methyl-1-piperazinyl)imino]methyl]rifamycin; 5,6,9,17,19,21-Hexahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-8-[N-(4-methyl-1-piperazinyl)formimidoyl]-2,7-(epoxypentadeca[1,11,13]trienimino)naphtho[2,1-b]furan-1,11(2H)-dione 21-acetate
EINECS	236-312-0

Quality Control

Our Rifampicin is manufactured under strict quality management systems. It is tested to meet relevant pharmacopoeial standards such as USP, EP, and BP, ensuring identity, purity, strength, and composition. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing results for assay, related substances, residual solvents, and microbiological quality. We provide material suitable for GMP manufacturing processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and easily oxidized; prolonged exposure to air and light should be avoided to maintain stability and potency. For long-term storage, consider an inert atmosphere.

Specification

Item	Specification
Appearance	Reddish-brown crystalline powder
Identification (IR)	Conforms to standard
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	97.0% - 102.0% (on dried basis)
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 3.0% Any individual impurity ≤ 1.0%
Heavy Metals	≤ 20 ppm
Microbial Limits	Conforms to EP/USP requirements

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.