Description

Rifamycin S is a key ansamycin antibiotic intermediate and a vital precursor in the synthesis of clinically important rifamycin derivatives. Its significance lies in its potent antibacterial activity against Gram-positive bacteria and its role as a foundational building block for advanced pharmaceutical manufacturing. This compound is essential for research institutions, pharmaceutical companies, and fine chemical suppliers engaged in antibiotic development, microbiological studies, and the production of active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Primary use as a crucial precursor in the synthesis of semi-synthetic rifamycin antibiotics like Rifampicin and Rifaximin.
• Antibacterial Research: Serves as a reference standard and active compound in microbiological assays and studies targeting bacterial RNA polymerase.
• Active Pharmaceutical Ingredient (API) Manufacturing: Used in the controlled production of finished antibiotic dosage forms under Good Manufacturing Practice (GMP) conditions.
• Biochemical Research: Employed in molecular biology and biochemistry to study mechanisms of antibiotic action and bacterial resistance.
• Veterinary Medicine: Potential application in the development of antibacterial treatments for animal health.

Basic Information

Product Name	Rifamycin S
CAS No.	13553-79-2
Molecular Formula	C37H45NO12
Molecular Weight	695.75 g/mol
Synonyms	Rifamycin S; Rifamycin-S; Antibiotic LM 427; Rifamycin SV Precursor; Rifamycin S Sodium Salt (derivative); (12Z,14E,24E)-(2S,12S,13S,14R,15S,16R,17R,18R,19S,20S,21S,22R,23S)-5,6,9,17,19-Pentahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-1,11-dioxo-2,7-(epoxypentadeca[1,11,13]trienimino)benzofuro[4,5-e]pyrido[1,2-a]benzimidazole-8-carboxylic Acid; Rifamycin S (free acid)
EINECS	236-932-1

Quality Control

Our Rifamycin S is produced and tested to meet high-purity standards suitable for pharmaceutical research and intermediate synthesis. Quality is assured through rigorous analytical controls including HPLC for purity, identity confirmation by spectroscopic methods, and stringent limits for related substances. A comprehensive Certificate of Analysis (COA) is provided with each batch, detailing all test results against established specifications. We support compliance with relevant pharmacopeial guidelines and customer-specific requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is light-sensitive (store away from light) and easily oxidized (store under inert atmosphere). For long-term storage, consider keeping the container under an inert gas atmosphere such as nitrogen or argon to maintain stability and potency.

Specification

Item	Specification
Appearance	Orange-red to brownish-red crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 3.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.