Description

4-o-Carboxymethyl-21-Deoxy-20-Hydroxy-21-Oxorifamycin is a key semi-synthetic derivative of the rifamycin class of antibiotics. This compound serves as a critical intermediate in the synthesis of advanced rifamycin-based pharmaceuticals, offering a versatile chemical handle for further derivatization. It is primarily required by pharmaceutical R&D laboratories and manufacturers developing next-generation antibacterial agents to combat resistant bacterial strains.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel rifamycin antibiotics with improved efficacy and pharmacokinetic profiles.
• Antibacterial Drug Development: Used in research programs targeting Gram-positive bacterial infections, including tuberculosis (TB) and methicillin-resistant *Staphylococcus aureus* (MRSA).
• Chemical Biology Research: Employed as a probe to study bacterial RNA polymerase inhibition mechanisms and structure-activity relationships (SAR).
• API Synthesis: Serves as a precursor in the multi-step manufacturing process of active pharmaceutical ingredients (APIs) for anti-infective medications.

Basic Information

Product Name	4-o-Carboxymethyl-21-Deoxy-20-Hydroxy-21-Oxorifamycin
CAS No.	15271-73-5
Molecular Formula	C38H47NO13
Molecular Weight	725.78 g/mol
Synonyms	4-Deoxy-4'-O-carboxymethylrifamycin S; 4-O-Carboxymethylrifamycin S; 21-Deoxy-20-hydroxy-21-oxorifamycin 4-O-carboxymethyl; Rifamycin S, 4-O-carboxymethyl-21-deoxy-20-hydroxy-21-oxo-; 4-O-(Carboxymethyl)-21-deoxy-20-hydroxy-21-oxorifamycin; 4-O-Carboxymethyl-21-deoxy-20-hydroxy-21-oxorifamycin S; Rifamycin derivative 15271-73-5
EINECS	Contact for details

Quality Control

Our 4-o-Carboxymethyl-21-Deoxy-20-Hydroxy-21-Oxorifamycin is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for pharmaceutical intermediate applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). This compound is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	Reddish-brown to orange powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 3.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.