Description

4-o-(Carboxymethyl)Rifamycin is a chemically modified derivative of the potent ansamycin antibiotic rifamycin. This compound serves as a crucial intermediate in the synthesis of advanced semi-synthetic rifamycin antibiotics, which are vital for treating serious bacterial infections. It is primarily required by pharmaceutical manufacturers and research institutions engaged in the development of next-generation antimicrobial agents and novel drug delivery systems.

Application

• Pharmaceutical Intermediate: Key starting material for the synthesis of semi-synthetic rifamycin antibiotics like rifampicin, rifabutin, and rifapentine.
• Antimicrobial Research: Used in biochemical and microbiological research to study structure-activity relationships (SAR) and develop new antibacterial compounds.
• API Manufacturing: Serves as a critical building block in the commercial production of Active Pharmaceutical Ingredients (APIs) for tuberculosis and other mycobacterial infection treatments.
• Conjugate Development: Utilized in the creation of antibiotic conjugates and prodrugs aimed at improving bioavailability and targeting specific pathogens.
• Reference Standard: Acts as a high-purity chemical reference standard for quality control and analytical method development in pharmaceutical labs.

Basic Information

Product Name	4-o-(Carboxymethyl)Rifamycin
CAS No.	13929-35-6
Molecular Formula	C38H47NO13
Molecular Weight	725.78 g/mol
Synonyms	Rifamycin O-carboxymethyl ether; 4-Deoxy-3,4-didehydro-4-O-(carboxymethyl)rifamycin SV; 4-O-(Carboxymethyl)rifamycin S; 4-O-Carboxymethylrifamycin; Rifamycin 4-O-(carboxymethyl) ether; 3-[[(4-Methyl-1-piperazinyl)imino]methyl]rifamycin; (2S,12Z,14E,16S,17S,18R,19R,20R,21S,22R,23S,24E)-21-Acetoxy-6,9,17,19-tetrahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-1,11-dioxo-1,2-dihydro-2,7-(epoxypentadeca[1,11,13]trienimino)naphtho[2,1-b]furan-5-carboxylic acid
EINECS	Contact for details

Quality Control

Our 4-o-(Carboxymethyl)Rifamycin is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets high-grade pharmaceutical intermediate standards. Certificates of Analysis (COA) with detailed specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) under an inert atmosphere (e.g., nitrogen or argon) to prevent oxidation. Keep the container in a cool, dry, and well-ventilated area, away from incompatible materials.

Specification

Item	Specification
Appearance	Orange to red-brown powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 95.0%
Water Content	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.